From l-α-aminobutyric acid (Abu) a set of electrophilic and non-electrophilic replacements
for the P1 cysteine of substrate and product inhibitors of hepatitis C virus full-length NS3 …

A library of tetrapeptides was evaluated for Hepatitis C Virus NS3 protease inhibitor activity
in an in vitro assay system comprising the native bifunctional full-length NS3 (protease …

Synthesis and inhibitory potencies of three types of protease inhibitors of the hepatitis C
virus (HCV) full-length NS3 (protease-helicase/NTPase) are reported:(i) inhibitors …

The structure− activity relationship at the C-terminal position of peptide-based inhibitors of
the hepatitis C virus NS3 protease is presented. The observation that the N-terminal …

Molecular modeling and inhibitory potencies of tetrapeptide protease inhibitors of HCV NS3
proposed phenylglycine as a new promising P2 residue. The results suggest that …

Structure–activity relationships (SARs) of product-based inhibitors of hepatitis C virus NS3
protease were evaluated using an in vitro assay system comprising the native bifunctional …

C-Terminal carboxylic acid containing inhibitors of the NS3 protease are reported. A novel
series of linear tripeptide inhibitors that are very potent and selective against the NS3 …

The hepatitis C virus (HCV) NS3 protease has emerged as a promising anti-HCV drug
target. Herein, we present an investigation of NS3 inhibitors comprising the acyl sulfonamide …

Starting from the previously reported HCV NS3/4A protease inhibitor BILN 2061 (1), we have
used a fast-follower approach to identify a novel series of HCV NS3/4A protease inhibitors in …

The NS3 serine protease enzyme of the hepatitis C virus (HCV) is essential for viral
replication. Short peptides mimicking the N-terminal substrate cleavage products of the NS3 …