We investigated the immune responses in mice lacking CCR2, CCR5, or macrophage
inflammatory protein-1α (MIP-1α), a ligand for CCR5, in two situations: following T cell …

The encounter between APC and T cells is crucial for initiating immune responses to
infectious microorganisms. In the spleen, interaction between dendritic cells (DC) and T cells …

Control of Leishmania donovani infection in immunocompetent mice is associated with
hepatic inflammation and granuloma formation, both of which are absent in severe …

Neutrophils are rapidly and massively recruited to sites of microbial infection, where they
can influence the recruitment of dendritic cells. Here, we have analyzed the role of …

The protein kinase C (PKC) family regulates macrophage function involved in host defense
against infection. In the case of Leishmania donovani infection, the impairment of PKC …

Transgenic Leishmania parasites that encode the murine chemokine monocyte
chemoattractant protein 1 (MCP-1) were generated. These parasites transcribed MCP-1 …

The chemokine CCL7 (MCP3) is known to promote the recruitment of many innate immune
cell types including monocytes and neutrophils to sites of bacterial and viral infection and …

Leishmania amazonensis can cause progressive disease in most inbred strains of mice. We
have previously shown that L. amazonensis-infected C57BL/6 mice have profound …

We postulated that CCR2-driven activation of the transcription factor NF-κB plays a critical
role in dendritic cell (DC) maturation (eg, migration, costimulation, and IL-12p70 production) …

Inflammatory monocytes can be manipulated by environmental cues to perform multiple
functions. To define the role of monocytes during primary or secondary infection with an intra …