Periventricular leukomalacia is the predominant injury in the preterm infant leading to
cerebral palsy. Oxygen exposure may be an additional cause of brain injury in these infants …

Periventricular leukomalacia, the predominant pathological lesion underlying cerebral palsy
in premature infants, is thought to be the result of hypoxic–ischemic injury to the cerebral …

In the premature infant, hypoxic-ischemic damage to the cerebral white matter
[periventricular leukomalacia (PVL)] is a common and leading cause of brain injury that often …

Approximately 10% of newborns are born prematurely. Of these children, more than 10%
will sustain neurological injuries leading to significant learning disabilities, cerebral palsy, or …

Background: Periventricular leukomalacia (PVL) affects the developing white matter of
neonatal brain. Inflammatory and infectious conditions are implicated in the cause of PVL …

Periventricular leukomalacia (PVL) involves free radical injury to developing
oligodendrocytes (OLs), resulting from ischemia/reperfusion, particularly between 24 and 32 …

Hypoxia-ischemia (HI) is a leading cause of white matter damage, a major contributor to
cerebral palsy in premature infants. Preferential white matter damage is believed to result …

The role of the cerebral cortex in the cognitive deficits in preterm survivors is poorly
understood. Periventricular leukomalacia (PVL), the key feature of encephalopathy of …

Objective: The major form of magnetic resonance imaging–defined white matter injury (WMI)
comprises diffuse lesions where the burden of small necrotic foci (microscopic necrosis) is …

Damage to oligodendrocyte (OL) progenitor cells (OPCs) and hypomyelination are two
hallmark features of periventricular leukomalacia (PVL), the most common form of brain …