Objective Periventricular leukomalacia is the predominant type of brain injury in preterm
infants underlying the development of cerebral palsy. Periventricular leukomalacia has its …

The present study examined factors that may be involved in the development of hypoxic
periventricular white matter damage in the neonatal brain. Wistar rats (1‐day old) were …

The development of a rodent model in the perinatal rat or mouse that reproduces the
principal features of human perinatal white matter injury (periventricular leukomalacia) has …

Preterm neonates are surviving with a milder spectrum of motor and cognitive disabilities
that appear to be related to widespread disturbances in cell maturation that target cerebral …

refer to “white matter damage,” whereas Inder et al3 speak of “periventricular leukomalacia.”
WMD is a term that encompasses a variety of pathologic entities, held together by one …

Periventricular leucomalacia is a condition that causes lifelong disability and considerable
economic burden. It occurs in premature infants of less than 32 weeks gestation due to their …

Cerebral hypoxia/ischemia of the newborn has a frequency of 4/1,000 births and remains a
major cause of cerebral palsy, epilepsy, and mental retardation. Despite progress in …

Studies of ischemic brain injury in neonatal rodents have focused upon the pathophysiology
of neuronal damage. Much less consideration has been given to white matter injury, even …

Reactive microglia and astrocytes are present in lesions of white matter disorders, such as
periventricular leukomalacia and multiple sclerosis. However, it is not clear whether they are …

Newborn neurological injuries are the leading cause of intellectual and motor disabilities
that are associated with cerebral palsy. Cerebral white matter injury is a common feature in …