Rationale Cocaine dependence is characterized by compulsive drug taking that supercedes
other recreational, occupational or social pursuits. We hypothesized that rats vulnerable to …

Animal models of addictive behaviors are useful for uncovering neural mechanisms involved
in the development of dependence and for identifying risk factors for drug abuse. One such …

The link between social influence and drug abuse has long been established in humans.
However, preclinical animal models of drug abuse have only recently begun to consider the …

Positive social interactions are essential for emotional well-being, healthy development,
establishment and maintenance of adequate social structures and reproductive success of …

Since the first experimental hint for the existence of “an actual desire or striving for the drug”
in nonhuman animals by Sidney Spragg in the late 1930s, much effort has been expended …

Research involving animal models of drug addiction can be viewed as a sort of reverse
psychiatry. Contrary to clinicians who seek to treat addicted people to become and remain …

Understanding the neurobiology of motivation might help in reducing compulsive behaviors
such as drug addiction or eating disorders. This study shows that excitatory synaptic …

Decisions that favor one's own interest versus the interest of another individual depend on
context and the relationships between individuals. The neurobiology underlying selfish …

Successful treatment of drug addiction must involve relapse prevention informed by our
understanding of the neurobiological bases of drug relapse. In humans, exposure to drug …

Background Pre‐clinical research involving non‐human animals has made important
contributions to our understanding of risk factors for addiction, neuroadaptations that follow …