Mucosal proliferation, together with differentiation and apoptosis, are a continuous
homeostatic process in the intestinal epithelium. The glutathione/glutathione disulfide redox …

The intestinal epithelium sits at the interface between an organism and its luminal
environment, and as such is prone to oxidative damage induced by luminal oxidants …

The intestinal tract, known for its capability for self-renew, represents the first barrier of
defence between the organism and its luminal environment. The thiol/disulfide redox …

Cellular redox, maintained by the glutathione (GSH)-and thioredoxin (Trx)-dependent
systems, has been implicated in the regulation of a variety of biological processes. The …

Redox signaling regulates physiological self-renewal, proliferation, migration and
differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch …

Redox signalling in the gastrointestinal mucosa is held in an intricate balance. Potent
microbicidal mechanisms can be used by infiltrating immune cells, such as neutrophils, to …

Changes in intracellular redox couples and redox reactive molecules have been implicated
in the regulation of a variety of cellular processes, including cell proliferation and growth …

Glutamine (Gln) and keratinocyte growth factor (KGF) each stimulate intestinal epithelial cell
growth, but regulatory mechanisms are not well understood. We determined whether Gln …

Apoptosis plays a critical role in maintaining homeostasis of the intestinal epithelium. Dietary
oxidants like peroxidized lipids could perturb cellular redox status and disrupt mucosal …

Cells maintain a reduced intracellular state in the face of a highly oxidizing extracellular
environment. Redox signalling pathways provide a link between external stimuli, through the …