Cellular redox: a modulator of intestinal epithelial cell proliferation
TY Aw - Physiology, 2003 - journals.physiology.org
Mucosal proliferation, together with differentiation and apoptosis, are a continuous
homeostatic process in the intestinal epithelium. The glutathione/glutathione disulfide redox …
homeostatic process in the intestinal epithelium. The glutathione/glutathione disulfide redox …
Intestinal redox biology and oxidative stress
ML Circu, TY Aw - Seminars in cell & developmental biology, 2012 - Elsevier
The intestinal epithelium sits at the interface between an organism and its luminal
environment, and as such is prone to oxidative damage induced by luminal oxidants …
environment, and as such is prone to oxidative damage induced by luminal oxidants …
Redox biology of the intestine
ML Circu, TY Aw - Free radical research, 2011 - Taylor & Francis
The intestinal tract, known for its capability for self-renew, represents the first barrier of
defence between the organism and its luminal environment. The thiol/disulfide redox …
defence between the organism and its luminal environment. The thiol/disulfide redox …
Glutathione and thioredoxin redox during differentiation in human colon epithelial (Caco-2) cells
YS Nkabyo, TR Ziegler, LH Gu… - American Journal of …, 2002 - journals.physiology.org
Cellular redox, maintained by the glutathione (GSH)-and thioredoxin (Trx)-dependent
systems, has been implicated in the regulation of a variety of biological processes. The …
systems, has been implicated in the regulation of a variety of biological processes. The …
Redox signaling in the gastrointestinal tract
S Pérez, R Taléns-Visconti, S Rius-Pérez… - Free Radical Biology …, 2017 - Elsevier
Redox signaling regulates physiological self-renewal, proliferation, migration and
differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch …
differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch …
Control and dysregulation of redox signalling in the gastrointestinal tract
EL Campbell, SP Colgan - Nature Reviews Gastroenterology & …, 2019 - nature.com
Redox signalling in the gastrointestinal mucosa is held in an intricate balance. Potent
microbicidal mechanisms can be used by infiltrating immune cells, such as neutrophils, to …
microbicidal mechanisms can be used by infiltrating immune cells, such as neutrophils, to …
Temporal changes of multiple redox couples from proliferation to growth arrest in IEC-6 intestinal epithelial cells
MS Attene-Ramos… - … of Physiology-Cell …, 2005 - journals.physiology.org
Changes in intracellular redox couples and redox reactive molecules have been implicated
in the regulation of a variety of cellular processes, including cell proliferation and growth …
in the regulation of a variety of cellular processes, including cell proliferation and growth …
Glutamine and KGF each regulate extracellular thiol/disulfide redox and enhance proliferation in Caco-2 cells
CR Jonas, LH Gu, YS Nkabyo… - American Journal …, 2003 - journals.physiology.org
Glutamine (Gln) and keratinocyte growth factor (KGF) each stimulate intestinal epithelial cell
growth, but regulatory mechanisms are not well understood. We determined whether Gln …
growth, but regulatory mechanisms are not well understood. We determined whether Gln …
Lipid hydroperoxide‐induced apoptosis in human colonic CaCo‐2 cells is associated with an early loss of cellular redox balance
TG Wang, Y Gotoh, MH Jennings… - The FASEB …, 2000 - Wiley Online Library
Apoptosis plays a critical role in maintaining homeostasis of the intestinal epithelium. Dietary
oxidants like peroxidized lipids could perturb cellular redox status and disrupt mucosal …
oxidants like peroxidized lipids could perturb cellular redox status and disrupt mucosal …
Redox signalling and the control of cell growth and death
G Powis, M Briehl, J Oblong - Pharmacology & therapeutics, 1995 - Elsevier
Cells maintain a reduced intracellular state in the face of a highly oxidizing extracellular
environment. Redox signalling pathways provide a link between external stimuli, through the …
environment. Redox signalling pathways provide a link between external stimuli, through the …