Prevalence of obesity in the general population has increased in the past 15 years from 15%
to 35%. With increasing obesity, the coincident medical and social consequences are …

There is increasing evidence demonstrating that reward-related motivational food intake is
closely connected with the brain's homeostatic system of energy balance and that this …

The hypothalamus integrates various hormonal and neuronal signals to regulate appetite
and metabolism and thereby serves a homeostatic purpose in the regulation of body weight …

The new lifestyle in the modern world is causing a rapid increase in the prevalence of
obesity and associated health problems. Increased availability of palatable and energy …

Obesity has reached epidemic prevalence, and much research has focused on homeostatic
and nonhomeostatic mechanisms underlying overconsumption of food. Mesocorticolimbic …

Recent evidence has emerged demonstrating that metabolic hormones such as ghrelin and
leptin can act on ventral tegmental area (VTA) midbrain dopamine neurons to influence …

The increased incidence of obesity makes it imperative to understand the regulation of food
intake and body weight. We review the signals that interact with the brain to control energy …

The ability to resist the urge to eat requires the proper functioning of neuronal circuits
involved in top-down control to oppose the conditioned responses that predict reward from …

Our understanding of the physiological systems that regulate food intake and body weight
has increased immensely over the past decade. Brain centres, including the hypothalamus …

The realization that there is nothing wrong with the homeostatic regulatory system in
common obesity suggests that a systematic investigation of pathways that link the …