Exosome-based immunotherapy: a promising approach for cancer treatment
Z Xu, S Zeng, Z Gong, Y Yan - Molecular cancer, 2020 - Springer
In the era of the rapid development of cancer immunotherapy, there is a high level of interest
in the application of cell-released small vesicles that stimulate the immune system. As cell …
in the application of cell-released small vesicles that stimulate the immune system. As cell …
NK cell–derived exosomes from NK cells previously exposed to neuroblastoma cells augment the antitumor activity of cytokine-activated NK cells
Immune cell–derived exosomes can increase immunity against tumors. In contrast, tumor-
derived exosomes can reduce the immunity and can change the tumor microenvironment to …
derived exosomes can reduce the immunity and can change the tumor microenvironment to …
Complete remission of tumors in mice with neoantigen-painted exosomes and anti-PD-1 therapy
Y Zhang, B Zuo, Z Yu, K Zhao, Y Zhang, K He, Y Seow… - Molecular Therapy, 2023 - cell.com
Neoantigen-based cancer vaccines are emerging as promising tumor therapies, but
enhancement of immunogenicity can further improve therapeutic outcomes. Here, we …
enhancement of immunogenicity can further improve therapeutic outcomes. Here, we …
Co-delivery of tumor-derived exosomes with alpha-galactosylceramide on dendritic cell-based immunotherapy for glioblastoma
Dendritic cell (DC) vaccine–based immunotherapy for glioblastoma multiforme (GBM) has
shown apparent benefit in animal experiments and early-phase clinical trials, but the …
shown apparent benefit in animal experiments and early-phase clinical trials, but the …
Personalized medicine and back–allogeneic exosomes for cancer immunotherapy
M Samuel, S Gabrielsson - Journal of internal medicine, 2021 - Wiley Online Library
Extracellular vesicles, especially exosomes, have been explored for cancer immunotherapy.
The initial studies made use of autologous B‐cell or dendritic cell‐derived exosomes, with …
The initial studies made use of autologous B‐cell or dendritic cell‐derived exosomes, with …
Modification of immune cell-derived exosomes for enhanced cancer immunotherapy: current advances and therapeutic applications
Cancer immunotherapy has revolutionized the approach to cancer treatment of malignant
tumors by harnessing the body's immune system to selectively target cancer cells. Despite …
tumors by harnessing the body's immune system to selectively target cancer cells. Despite …
Recent advances in exosome-based immunotherapy applied to cancer
Cancer stands as a prominent contributor to global mortality rates, necessitating immediate
attention toward the exploration of its treatment options. Extracellular vesicles have been …
attention toward the exploration of its treatment options. Extracellular vesicles have been …
Tumor-derived exosomes: the next generation of promising cell-free vaccines in cancer immunotherapy
M Naseri, M Bozorgmehr, M Zöller… - …, 2020 - Taylor & Francis
Identification of immunogenic tumor antigens that are efficiently processed and delivered by
dendritic cells to prime the immune system and to induce an appropriate immune response …
dendritic cells to prime the immune system and to induce an appropriate immune response …
Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy
R Hosseini, H Sarvnaz, M Arabpour, SM Ramshe… - Molecular cancer, 2022 - Springer
Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is
now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity …
now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity …
TGF-β1-silenced leukemia cell-derived exosomes target dendritic cells to induce potent anti-leukemic immunity in a mouse model
F Huang, J Wan, S Hao, X Deng, L Chen… - Cancer Immunology …, 2017 - Springer
Tumor-derived exosomes (TEX) can induce a specific antitumor immune response and have
been developed as a promising tumor vaccine. Despite promising preclinical data, TEX …
been developed as a promising tumor vaccine. Despite promising preclinical data, TEX …