Human monoclonal antibodies neutralizing influenza virus A/H1N1pdm09 and seasonal A/H1N1 strains–Distinct Ig gene repertoires with a similar action mechanism

S Hiroi, M Kuhara, Y Kishi, K Ono, S Matsuzawa… - Immunobiology, 2018 - Elsevier
Influenza virus causes acute respiratory infection in humans, and is a major public health
concern globally. Antibodies play a central role in host protection against influenza virus. We …

Human monoclonal antibodies derived from a patient infected with 2009 pandemic influenza A virus broadly cross-neutralize group 1 influenza viruses

Y Pan, T Sasaki, R Kubota-Koketsu, Y Inoue… - Biochemical and …, 2014 - Elsevier
Influenza viruses are a continuous threat to human public health because of their ability to
evolve rapidly through genetic drift and reassortment. Three human monoclonal antibodies …

Pre-and postexposure use of human monoclonal antibody against H5N1 and H1N1 influenza virus in mice: viable alternative to oseltamivir

W Koudstaal, MH Koldijk, JPJ Brakenhoff… - The Journal of …, 2009 - academic.oup.com
New strategies to prevent and treat influenza virus infections are urgently needed. A recently
discovered class of monoclonal antibodies (mAbs) neutralizing an unprecedented spectrum …

[HTML][HTML] Neutralization activity of influenza A virus humanized antibodies against new subtypes of influenza viruses

J Liu, T Wang, Y Xie, Y Li, J He, X Zhang, W Sun… - Biosafety and …, 2019 - Elsevier
Antibodies are ideal for controlling the influenza A virus, but their effect on newly emerging
strains is unclear. Here, we assessed the neutralization activity of the humanized …

[HTML][HTML] Identification of broad-spectrum neutralizing antibodies against influenza A virus and evaluation of their prophylactic efficacy in mice

S Son, SB Ahn, G Kim, Y Jang, C Ko, M Kim, SJ Kim - Antiviral Research, 2023 - Elsevier
Influenza A virus continuously infects humans and the antigenic shifts of this respiratory virus
enable it to cross the species barrier, threatening public health with the risk of pandemics …

Human single-chain antibodies that neutralize homologous and heterologous strains and clades of influenza A virus subtype H5N1

S Maneewatch, J Thanongsaksrikul… - Antiviral …, 2009 - journals.sagepub.com
Background Human antibodies that interfere with the biological activity of haemagglutinins
(HAs) of influenza viruses have high potential as an antiviral agent. Methods Human single …

Broadly reactive human monoclonal antibodies elicited following pandemic H1N1 influenza virus exposure protect mice against highly pathogenic H5N1 challenge

R Nachbagauer, D Shore, H Yang, SK Johnson… - Journal of …, 2018 - Am Soc Microbiol
Broadly cross-reactive antibodies (Abs) that recognize conserved epitopes within the
influenza virus hemagglutinin (HA) stalk domain are of particular interest for their potential …

Evaluation of neutralizing efficacy of monoclonal antibodies specific for 2009 pandemic H1N1 influenza A virus in vitro and in vivo

J Chen, B Yan, Q Chen, Y Yao, H Wang, Q Liu… - Archives of …, 2014 - Springer
Pandemic influenza A virus (H1N1) 2009 poses a serious public-health challenge
worldwide. To characterize the neutralizing epitopes of this virus, we generated a panel of …

Neutralization and binding profile of monoclonal antibodies generated against influenza A H1N1 Viruses

N Shembekar, VVA Mallajosyula, A Malik… - Monoclonal …, 2016 - liebertpub.com
Monoclonal antibodies (MAbs) provide scope for the development of better therapeutics and
diagnostic tools. Herein, we describe the binding and neutralization profile (s) for a panel of …

Generation and characterization of monoclonal antibodies against the hemagglutinin of H3N2 influenza A viruses

F Yang, L Zhu, F Liu, L Cheng, H Yao, N Wu, H Wu, L Li - Virus Research, 2022 - Elsevier
Seasonal influenza viruses are highly contagious, leading to 290,000–650,000 mortalities
every year globally. Among the influenza viruses, influenza A virus (H3N2) has attracted …