Neutralizing human monoclonal antibody against H5N1 influenza HA selected from a Fab-phage display library

APC Lim, CEZ Chan, SKK Wong, AHY Chan, EE Ooi… - Virology journal, 2008 - Springer
Identification of neutralizing antibodies with specificity away from the traditional mutation
prone antigenic regions, against the conserved regions of hemagglutinin from H5N1 …

Cross-protective potential of anti-nucleoprotein human monoclonal antibodies against lethal influenza A virus infection

Y Fujimoto, Y Tomioka, H Takakuwa… - Journal of General …, 2016 - microbiologyresearch.org
The nucleoprotein (NP) possesses regions that are highly conserved among influenza A
viruses, and has therefore been one of the target viral proteins for development of a …

Specific recognition of influenza A/H1N1/2009 antibodies in human serum: a simple virus-free ELISA method

MM Alvarez, F López-Pacheco, JM Aguilar-Yanez… - PloS one, 2010 - journals.plos.org
Background Although it has been estimated that pandemic Influenza A H1N1/2009 has
infected millions of people from April to October 2009, a more precise figure requires a …

Antibodies against swine influenza virus neutralize the pandemic influenza virus A/H1N1

M Tsukamoto, S Hiroi, K Adachi… - Molecular …, 2011 - spandidos-publications.com
The most effective method for the prevention of influenza infection would be prophylaxis with
a safe and effective vaccine and anti-viral materials. After vaccination, neutralizing …

A novel humanized antibody neutralizes H5N1 influenza virus via two different mechanisms

Y Tan, Q Ng, Q Jia, J Kwang, F He - Journal of Virology, 2015 - Am Soc Microbiol
Highly pathogenic avian influenza virus subtype H5N1 continues to be a severe threat to
public health, as well as the poultry industry, because of its high lethality and antigenic drift …

A pan-influenza monoclonal antibody neutralizes H5 strains and prophylactically protects through intranasal administration

AL Beukenhorst, J Frallicciardi, KL Rice, MH Koldijk… - Scientific Reports, 2024 - nature.com
Abstract Avian A (H5N1) influenza virus poses an elevated zoonotic threat to humans, and
no pharmacological products are currently registered for fast-acting pre-exposure protection …

Identification of amino acid substitutions supporting antigenic change of influenza A (H1N1) pdm09 viruses

BF Koel, R Mögling, S Chutinimitkul, PL Fraaij… - Journal of …, 2015 - Am Soc Microbiol
The majority of currently circulating influenza A (H1N1) viruses are antigenically similar to
the virus that caused the 2009 influenza pandemic. However, antigenic variants are …

Antibody pressure by a human monoclonal antibody targeting the 2009 pandemic H1N1 virus hemagglutinin drives the emergence of a virus with increased virulence …

CD O'Donnell, L Vogel, A Wright, SR Das, J Wrammert… - MBio, 2012 - Am Soc Microbiol
In 2009, a novel H1N1 influenza A virus (2009 pH1N1) emerged and caused a pandemic. A
human monoclonal antibody (hMAb; EM4C04), highly specific for the 2009 pH1N1 virus …

Prophylactic and therapeutic efficacy of avian antibodies against influenza virus H5N1 and H1N1 in mice

HH Nguyen, TM Tumpey, HJ Park, YH Byun, LD Tran… - PloS one, 2010 - journals.plos.org
Background Pandemic influenza poses a serious threat to global health and the world
economy. While vaccines are currently under development, passive immunization could …

Subclade 2.2. 1-specific human monoclonal antibodies that recognize an epitope in antigenic site A of influenza A (H5) virus HA detected between 2015 and 2018

M Okuda, S Yamayoshi, R Uraki, M Ito, T Hamabata… - Viruses, 2019 - mdpi.com
Highly pathogenic avian H5 influenza viruses persist among poultry and wild birds
throughout the world. They sometimes cause interspecies transmission between avian and …