Cryptococcosis, caused by the basidiomycete Cryptococcus neoformans, is a life-
threatening disease affecting approximately one million people per year worldwide. Infection …

Macrophages are innate immune cells that possess unique abilities to polarize toward
different phenotypes. Classically activated macrophages are known to have major roles in …

Induction of IL-12 and IL-23 is essential for protective immunity against Cryptococcus
neoformans. The contribution of dendritic cells vs. macrophages to IL-12/23 production in …

Cryptococcus species, the etiological agents of cryptococcosis, are encapsulated fungal
yeasts that predominantly cause disease in immunocompromised individuals, and are …

Cryptococcus neoformans is an opportunistic fungal pathogen and a leading cause of death
in immunocompromised individuals. The interactions of this yeast with host phagocytes are …

Cryptococcus neoformans, the etiological agent of cryptococcosis, is an occasional
opportunistic fungal pathogen of immune competent individuals. However, it is a relatively …

Matrix metalloproteinases (MMPs) are a family of extracellular proteases that play roles in
regulating the immune response in inflammatory processes. Previous studies indicated that …

Susceptibility to infection with Cryptococcus neoformans is tightly determined by production
of IL-4. In this study, we investigated the time course of IL-4 production and its innate cellular …

Cryptococcal meningitis is the most common cause of meningitis among HIV/AIDS patients
in sub-Saharan Africa, and worldwide causes over 223,000 cases leading to more than …

The encapsulated fungal pathogen Cryptococcus neoformans represents a significant agent
of life-threatening infections in immunocompromised subjects. A unique characteristic of …