Neutrophils are critical as the first-line defense against fungal pathogens. Yet, previous
studies indicate that neutrophil function is complex during Cryptococcus neoformans (Cn) …

The mechanisms by which Cryptococcus neoformans persists in an immunocompetent host
are not well understood. Using a rat model of persistent infection, we investigated the ability …

Previous investigations have demonstrated that macrophages play a critical role in the first‐
line cellular defense mechanism against infection with Cryptococcus neoformans. In the …

The fungal pathogen Cryptococcus neoformans survives phagocytosis by macrophages and
proliferates within, ultimately establishing latent infection as a facultative intracellular …

Cryptococcus neoformans is a fungal pathogen with worldwide distribution. Serological
studies of human populations show a high prevalence of human infection, which rarely …

The substantial morbidity and mortality caused by invasive fungal pathogens, including
Cryptococcus neoformans, necessitates increased understanding of protective immune …

Rats and mice are considered resistant and susceptible hosts, respectively, for experimental
cryptococcosis. For both species, alveolar macrophages (AM) are central components of the …

Human infection with Cryptococcus neoformans, a common fungal pathogen, follows
deposition of yeast spores in the lung alveoli. The subsequent host–pathogen interaction …

Macrophages have a central role in the pathogenesis of cryptococcosis since they are an
important line of defense, serve as a site for fungal replication, and also can contribute to …

Cryptococcus neoformans is a fungal pathogen that causes almost half a million deaths
each year. It is believed that most humans are infected with C. neoformans, possibly in a …