Today cytochrome P450 (P450) research is accepted as an integral part of drug
development and discovery. Work leading to this point included biochemical studies on …

P450 enzymes comprise a superfamily of heme-containing proteins that catalyze oxidative
metabolism of structurally diverse chemicals. Over the past few years, there has been …

In the past decade there has been considerable progress in the characterization of
individual human P450 enzymes. These advances were initiated by early work on the …

As a result of technical advances in recombinant DNA technology and nucleotide
sequencing, entire genome sequences have become available in the past decade and offer …

Currently, the major recognized biochemical functions of members of the large superfamily
of P450 hemoproteins (referred to commonly as the cytochromes P450) include catalyses of …

This two volume set summarizes the current knowledge of mammalian cytochromes. Ten
chapters cover the current understanding of the enzymology of rat, rabbit, and human liver …

There is substantial evidence that all known P450s derive from a common ancestor/l/. Even
the most distant P450s share considerably more homology between themselves than with …

Cytochromes P450 are ubiquitous hemeproteins in living organisms. In fact, more than 500
different cytochromes P450 have been cloned and sequenced so far [25]. They have been …

We provide here a list of 221 P450 genes and 12 putative pseudogenes that have been
characterized as of December 14, 1992. These genes have been described in 31 …