Twenty years of biochemistry of human P450s: purification, expression, mechanism, and relevance to drugs
FP Guengerich, NA Hosea, A Parikh… - Drug Metabolism and …, 1998 - ASPET
Today cytochrome P450 (P450) research is accepted as an integral part of drug
development and discovery. Work leading to this point included biochemical studies on …
development and discovery. Work leading to this point included biochemical studies on …
Recent advances in P450 research
JL Raucy, SW Allen - The Pharmacogenomics Journal, 2001 - nature.com
P450 enzymes comprise a superfamily of heme-containing proteins that catalyze oxidative
metabolism of structurally diverse chemicals. Over the past few years, there has been …
metabolism of structurally diverse chemicals. Over the past few years, there has been …
Human cytochrome P450 enzymes
FP Guengerich - Cytochrome P450: structure, mechanism, and …, 1995 - Springer
In the past decade there has been considerable progress in the characterization of
individual human P450 enzymes. These advances were initiated by early work on the …
individual human P450 enzymes. These advances were initiated by early work on the …
Orphans in the human cytochrome P450 superfamily: approaches to discovering functions and relevance in pharmacology
FP Guengerich, Q Cheng - Pharmacological reviews, 2011 - ASPET
As a result of technical advances in recombinant DNA technology and nucleotide
sequencing, entire genome sequences have become available in the past decade and offer …
sequencing, entire genome sequences have become available in the past decade and offer …
Substrate specificities and functions of the P450 cytochromes
MR Juchau - Life Sciences, 1990 - Elsevier
Currently, the major recognized biochemical functions of members of the large superfamily
of P450 hemoproteins (referred to commonly as the cytochromes P450) include catalyses of …
of P450 hemoproteins (referred to commonly as the cytochromes P450) include catalyses of …
Mammalian Cytochromes P-450: Volume I and Volume II
FP Guengerich - 1987 - osti.gov
This two volume set summarizes the current knowledge of mammalian cytochromes. Ten
chapters cover the current understanding of the enzymology of rat, rabbit, and human liver …
chapters cover the current understanding of the enzymology of rat, rabbit, and human liver …
Diversity and evolution of plant P450 and P450-reductases
F Durst, DR Nelson - Drug metabolism and drug interactions, 1995 - degruyter.com
There is substantial evidence that all known P450s derive from a common ancestor/l/. Even
the most distant P450s share considerably more homology between themselves than with …
the most distant P450s share considerably more homology between themselves than with …
The great diversity of reactions catalyzed by cytochromes P450
D Mansuy - Comparative Biochemistry and Physiology Part C …, 1998 - Elsevier
Cytochromes P450 are ubiquitous hemeproteins in living organisms. In fact, more than 500
different cytochromes P450 have been cloned and sequenced so far [25]. They have been …
different cytochromes P450 have been cloned and sequenced so far [25]. They have been …
The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature
DR Nelson, T Kamataki, DJ Waxman… - DNA and cell …, 1993 - liebertpub.com
We provide here a list of 221 P450 genes and 12 putative pseudogenes that have been
characterized as of December 14, 1992. These genes have been described in 31 …
characterized as of December 14, 1992. These genes have been described in 31 …