Rationale Although high anxiety is commonly associated with drug addiction, its causal role
in this disorder is unclear. Objectives In light of strong evidence for dissociable neural …

BACKGROUND: Cocaine is a widely abused psychostimulant that has both rewarding and
aversive properties. While the mechanisms underlying cocaine's rewarding effects have …

Numerous clinical studies have indicated that lifetime anxiety is highly prevalent in drug
addicts. In the treatment of drug abuse, dually diagnosed drug addicts may benefit from …

The initial termination of cocaine consumption in human addicts is associated with
heightened anxiety states and low levels of craving. Craving, however, tends to increase …

BACKGROUND: Clinical observations suggest that cocaine addiction often emerges with
new patterns of use. Whether these changes are a cause of addiction or its consequence is …

Discontinuation of drug intake in cocaine abusers commonly produces a variety of adverse
withdrawal symptoms among which anxiety and depression-related behavior are prevailing …

Sensation/novelty-seeking is amongst the best markers of cocaine addiction in humans.
However, its implication in the vulnerability to cocaine addiction is still a matter of debate, as …

Research into factors that determine the propensity to self-administer cocaine has shown
that stressors can determine the amount of cocaine self-administered as well as the rate of …

Heightened sensation seeking is associated with an increased risk of substance use
disorder in clinical populations. In rats, sensation seeking is often examined by measuring …

Drug addiction is a chronic disease defined by a complex set of characteristics, including
loss of control over drug intake and persistent drug craving, which primarily affects a small …