Just as normal stem cells require niche cells for survival, leukemia-initiating cells (LICs) may
also require niche cells for their maintenance. Chronic myeloid leukemia (CML) is caused by …

Highlights•CD25 is a novel STAT5-dependent marker of leukemic stem cells (LSCs) in
CML.•In chronic phase CML, LSCs are usually CD25+/CD26+/IL-1RAP+.•CD25 is a …

CD25 is expressed on leukemic cells in 10–20% cases of acute myeloid leukemia (AML),
and its expression is associated with poor prognosis. We reevaluated the relationship …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder characterized by a
chromosome translocation that generates the Bcr-Abl oncogene encoding a constitutive …

Despite the remarkable efficacy of tyrosine kinase inhibitors (TKIs) in eliminating
differentiated chronic myeloid leukemia (CML) cells, recent evidence suggests that leukemic …

Chronic myeloid leukemia (CML) has been studied intensively for many years; yet its
treatment remains problematic and its biology remains elusive. In chronic phase, the …

Using a mouse model recapitulating the main features of human chronic myelogenous
leukemia (CML), we uncover the hierarchy of leukemic stem and progenitor cells …

Abstract Treatment of chronic myelogenous leukemia (CML) with BCR-ABL tyrosine kinase
inhibitors (TKI) fails to eliminate leukemia stem cells (LSC). Patients remain at risk for …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasia arising from the
oncogenic break point cluster region/Abelson murine leukemia viral oncogene homolog 1 …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm driven by BCR-
ABL1 oncoprotein, which plays a pivotal role in CML pathology, diagnosis, and treatment as …