In the United States, sickle cell disease affects approximately 1 in 350 African-American
newborn infants each year, and approximately 72,000 individuals total. Sickle cell disease is …

Background: Sickle cell disease causes significant morbidity and mortality and affects the
economic and healthcare status of many countries. Yet historically, the disease has not had …

Sickle cell disease is an autosomal recessive, multisystem disorder, characterised by
chronic haemolytic anaemia, painful episodes of vaso-occlusion, progressive organ failure …

Serves as a guide for the health care worker involved in the management of patients with
sickle cell disease. Represents a collective summary of experiences with therapeutic …

The first clinical description of sickle cell anemia was published in 1910 by Herri~ k?~ who
reported some of the clinical and hematologic manifestations of the disorder in a 20-year-old …

The sickle hemoglobin is an abnormal hemoglobin due to point mutation (GAG→ GTG) in
exon 1 of the β globin gene resulting in the substitution of glutamic acid by valine at position …

Sickle cell disease results in significant morbidity and mortality for those affected with this
disease. Despite the fact that every case of sickle cell disease results from the same genetic …

Sickle-cell disease (SCD) is now a common condition in the UK and other European
countries. This is a consequence of the recent influx of immigrants from parts of the world …

Objectives: Identify the epidemiology of sickle cell disease. Describe the different types of
sickle cell crises. Review the treatment and management options available for sickle cell …

Over 70,000 people live with sickle cell disease in the United States and multitudes world
wide. About 2000 afflicted babies are born in this country each year. In African countries …