Serotonin, an important neuromodulator in the brain, is implicated in affective and cognitive
functions. However, its role even for basic cortical processes is controversial. For example …

To study the molecular mechanism how cortical areas are specialized in adult primates, we
searched for area-specific genes in macaque monkeys and found striking enrichment of …

Fundamental brain functions depend on a balance between excitation (E) and inhibition (I)
that is highly adjusted to a 20–80% set point in layer 5 pyramidal neurons (L5PNs) of rat …

Sensory perception arises from the integration of externally and internally driven
representations of the world. Disrupted balance of these representations can lead to …

Controlling gain of cortical activity is essential to modulate weights between internal ongoing
communication and external sensory drive. Here, we show that serotonergic input has …

The brain serotonin systems participate in numerous aspects of reward processing, although
it remains elusive how exactly serotonin signals regulate neural computation and reward …

The brain dynamically changes its input-output relationship depending on the behavioral
state and context in order to optimize information processing. At the molecular level …

Visual processing is dynamically controlled by multiple neuromodulatory molecules that
modify the responsiveness of neurons and the strength of the connections between them. In …

Background The central neuromodulator serotonin (5-HT) has been implicated in a wide
range of behaviors and affective disorders, but the principles underlying its function remain …

The serotonergic system has been widely studied across animal taxa and different functional
networks. This modulatory system is therefore well positioned to compare the consequences …