Activation of p38 mitogen‐activated protein kinase (p38) in spinal microglia is implicated in
spinal nociceptive processing. Minocycline, a tetracycline derivative, displays selective …

Activated glial cells (microglia and astroglia) in the spinal cord play a major role in mediating
enhanced pain states by releasing proinflammatory cytokines and other substances thought …

We have previously demonstrated that activation of p38 mitogen-activated protein kinase
(p38 MAPK) in the spinal microglia mediates morphine antinociceptive tolerance …

Glia, particularly astrocytes and microglia, are known to play an important role in central
sensitization and are strongly implicated in the exaggerated pain states. In the present study …

It has been demonstrated that spinal microglial activation is involved in formalin-induced
pain and that minocycline, an inhibitor of microglial activation, attenuate behavioral …

There is a paucity of data on the role of microglia and neuroinflammatory processes in the
association between chronic pain and depression. The current study examined the effect of …

Substantial evidence indicates involvement of microglia/macrophages in chronic
neuropathic pain. However, the temporal-spatial features of microglial/macrophage …

Microglia, the intrinsic macrophages of the central nervous system, have previously been
shown to be activated in the spinal cord in several rat mononeuropathy models. Activation of …

Systemic injection of lipopolysaccharide (LPS) induces a robust immune response as well
as thermal and mechanical hyperalgesia. Spinal and peripheral glial cells have been …

Neuropathic pain is an intractable clinical problem, affecting millions of people worldwide.
Preemptive administration of minocycline has been confirmed useful for treating neuropathic …