Dietary quercetin attenuates depressive-like behaviors by inhibiting astrocyte reactivation in response to stress

J Zhang, L Ning, J Wang - Biochemical and Biophysical Research …, 2020 - Elsevier
The mechanisms underlying the antidepressant activity of quercetin are unknown. We
investigated the effect of a quercetin-enriched diet (2 g/kg and 0.5 g/kg doses) on chronic …

Role of quercetin in depressive-like behaviors: Findings from animal models

S Silvestro, P Bramanti, E Mazzon - Applied Sciences, 2021 - mdpi.com
Depressive-like behavior is a highly prevalent worldwide neuropsychiatric disorder that
owns a complex pathophysiologic mechanism. The available pharmacotherapy is ineffective …

Quercetin mitigates depression-like behavior via the suppression of neuroinflammation and oxidative damage in corticosterone-induced mice

C Ge, S Wang, X Wu, L Lei - Journal of Chemical Neuroanatomy, 2023 - Elsevier
Depression is a clinically common and easily overlooked mental disease. Quercetin is a
flavonoid compound, which has anti-inflammatory and antioxidant roles. Previous reports …

Preventive putative mechanisms involved in the psychopathologies of mice passively coping with psychosocial defeat stress by quercetin

PI Ugwu, B Ben-Azu, SU Ugwu, CI Uruaka… - Brain Research …, 2022 - Elsevier
Derangements of neuroimmune, neurotrophic and neurochemical homeostasis have
important implications in psychosocial stress-induced psychopathologies. Whether …

Quercetin prevents chronic unpredictable stress induced behavioral dysfunction in mice by alleviating hippocampal oxidative and inflammatory stress

V Mehta, A Parashar, M Udayabanu - Physiology & Behavior, 2017 - Elsevier
It is now evident that chronic stress is associated with anxiety, depression and cognitive
dysfunction and very few studies have focused on identifying possible methods to prevent …

Quercetin reverses chronic unpredictable mild stress-induced depression-like behavior in vivo by involving nuclear factor-E2-related factor 2

Y Guan, J Wang, X Wu, L Song, Y Wang, M Gong, B Li - Brain Research, 2021 - Elsevier
Quercetin is a flavonoid compound rich in many natural plants with a wide range of
pharmacological effects and nutritional value. Although previous studies have initially shown …

Quercetin alleviates chronic unpredictable mild stress-induced depressive-like behaviors by promoting adult hippocampal neurogenesis via FoxG1/CREB/BDNF …

ZX Ma, RY Zhang, WJ Rui, ZQ Wang, X Feng - Behavioural brain research, 2021 - Elsevier
Quercetin, a naturally occurring flavonoid, has been reported to exert antidepressant effects,
however, the underlying mechanisms are still uncertain. Recent studies have demonstrated …

Suppressive effect of quercetin on acute stress-induced hypothalamic-pituitary-adrenal axis response in Wistar rats

K Kawabata, Y Kawai, J Terao - The Journal of nutritional biochemistry, 2010 - Elsevier
The flavonoid quercetin is considered to have beneficial effects on human health. We
recently have shown that quercetin-enriched foods reduced the duration of immobility time in …

Quercetin impairs learning and memory in normal mice via suppression of hippocampal phosphorylated cyclic AMP response element-binding protein expression

WY Jung, SJ Park, DH Park, JM Kim, DH Kim, JH Ryu - Toxicology Letters, 2010 - Elsevier
Quercetin is a naturally occurring dietary flavonol and several reports have shown that
quercetin substantially affects cognitive function in disease models, which suggests that …

Quercetin mitigates Adriamycin-induced anxiety-and depression-like behaviors, immune dysfunction, and brain oxidative stress in rats

S Merzoug, ML Toumi, A Tahraoui - Naunyn-Schmiedeberg's archives of …, 2014 - Springer
This study was designed to evaluate the effect of quercetin, a natural flavonoid, on
behavioral alterations, brain oxidative stress, and immune dysregulation caused by a …