Genome-wide association studies have identified single nucleotide polymorphisms (SNPs)
associated with waist circumference (WC) and waist-to-hip ratio (WHR) adjusted for BMI …

Purpose Obesity is a heterogeneous condition and distinct adiposity subtypes may
differentially affect type 2 diabetes risk. We assessed relations between genetically …

Although many individuals are able to achieve weight loss, maintaining this loss over time is
challenging. We aimed to study whether genetic predisposition to general or abdominal …

Clinically relevant weight loss is achievable through lifestyle modification, but unintentional
weight regain is common. We investigated whether recently discovered genetic variants …

Abstract Background/Aims: The present study identified genetic predictors of weight change
during behavioral weight loss treatment. Methods: Participants were 3,899 …

Objective: The well-established link between body fat distribution and metabolic health has
been suggested to act through an impact on the remodeling capacity of the adipose tissue …

Genome-wide association studies (GWAS) for BMI, waist-to-hip ratio, and other adiposity
traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although …

OBJECTIVE We tested genetic associations with weight loss and weight regain in the
Diabetes Prevention Program, a randomized controlled trial of weight loss–inducing …

Background While environmental factors play an important role in weight loss effectiveness,
genetics may also influence its success. We examined whether a genome-wide polygenic …

Importance In observational studies, abdominal adiposity has been associated with type 2
diabetes and coronary heart disease (CHD). Whether these associations represent causal …