The rapidly increasing availability of microbial genome sequences has led to a growing
demand for bioinformatics software tools that support the functional analysis based on the …

Background The introduction of next generation sequencing approaches has caused a rapid
increase in the number of completely sequenced genomes. As one result of this …

The EDGAR platform, a web server providing databases of precomputed orthology data for
thousands of microbial genomes, is one of the most established tools in the field of …

High throughput sequencing is now fast and cheap enough to be considered part of the
toolbox for investigating bacteria, and there are thousands of bacterial genome sequences …

ABSTRACT Since 2003, MicrobesOnline (http://www. microbesonline. org) has been
providing a community resource for comparative and functional genome analysis. The portal …

Motivation: The presence or absence of metabolic pathways and structures provide a
context that makes protein annotation far more reliable. Compiling such information across …

Large-scale mining and analysis of bacterial datasets contribute to the comprehensive
characterization of complex microbial dynamics within a microbiome and among different …

The initial outcome of genome sequencing is the creation of long text strings written in a four
letter alphabet. The role of in silico sequence analysis is to assist biologists in the act of …

Average nucleotide identity (ANI) was proposed almost 10 years ago as a means to
compare genetic relatedness among prokaryotic strains. It was found that values around …

We present here HOBACGEN, a database system devoted to comparative genomics in
bacteria. HOBACGEN contains all available protein genes from bacteria, archaea, and …