A chondroitin sulfate small molecule that stimulates neuronal growth

SE Tully, R Mabon, CI Gama, SM Tsai… - Journal of the …, 2004 - ACS Publications
Chondroitin sulfate glycosaminoglycans are sulfated polysaccharides involved in cell
division, neuronal development, and spinal cord injury. Here, we report the synthesis and …

Structural variation of chondroitin sulfate and its roles in the central nervous system

N Maeda - Central Nervous System Agents in Medicinal …, 2010 - ingentaconnect.com
Chondroitin sulfate is popular in the field of neuroscience, because the treatment of nervous
tissues with chondroitinase ABC, which degrades chondroitin sulfate up to unsaturated …

Sulfation patterns of glycosaminoglycans encode molecular recognition and activity

CI Gama, SE Tully, N Sotogaku, PM Clark… - Nature chemical …, 2006 - nature.com
Although glycosaminoglycans contribute to diverse physiological processes,,,, an
understanding of their molecular mechanisms has been hampered by the inability to access …

Chondroitin/dermatan sulfate in the central nervous system

K Sugahara, T Mikami - Current opinion in structural biology, 2007 - Elsevier
In the central nervous system (CNS) chondroitin sulfate proteoglycans, as one of the major
barrier-forming molecules, influence cell migration patterns and axon pathfinding. By …

Chondroitin-4-sulfation negatively regulates axonal guidance and growth

H Wang, Y Katagiri, TE McCann… - Journal of cell …, 2008 - journals.biologists.com
Glycosaminoglycan (GAG) side chains endow extracellular matrix proteoglycans with
diversity and complexity based upon the length, composition and charge distribution of the …

Neuroactive chondroitin sulfate glycomimetics

M Rawat, CI Gama, JB Matson… - Journal of the American …, 2008 - ACS Publications
We report the generation of chondroitin sulfate (CS) glycomimetics with tunable chemical
and biological properties. Our approach greatly simplifies the synthesis of complex …

[HTML][HTML] Chondroitin sulfate “wobble motifs” modulate maintenance and differentiation of neural stem cells and their progeny

A Purushothaman, K Sugahara, A Faissner - Journal of Biological …, 2012 - ASBMB
Chondroitin sulfate/dermatan sulfate (CS/DS) proteoglycans, major components of the
central nervous system, have the potential to interact with a wide range of growth factors and …

Expression of multiple chondroitin/dermatan sulfotransferases in the neurogenic regions of the embryonic and adult central nervous system implies that complex …

K Akita, A Von Holst, Y Furukawa, T Mikami… - Stem …, 2008 - academic.oup.com
Chondroitin/dermatan sulfotransferases (C/D-STs) underlie the synthesis of diverse sulfated
structures in chondroitin/dermatan sulfate (CS/DS) chains. Recent reports have suggested …

[HTML][HTML] Novel 70-kDa chondroitin sulfate/dermatan sulfate hybrid chains with a unique heterogenous sulfation pattern from shark skin, which exhibit neuritogenic …

CD Nandini, N Itoh, K Sugahara - Journal of Biological Chemistry, 2005 - ASBMB
Chondroitin sulfate (CS) and dermatan sulfate (DS) hybrid chains of proteoglycans are
critical in growth factor binding, neuritogenesis, and brain development. Here we isolated …

Structure and function of oversulfated chondroitin sulfate variants unique sulfation patterns and neuroregulatory activities

K Sugahara, S Yamada - Trends in Glycoscience and …, 2000 - jstage.jst.go.jp
抄録 多硫酸化コンドロイチン硫酸 (CS) には CS-D, CS-E, CS-H および CS-K があり,
いずれもジ硫酸化あるいはトリ硫酸化二糖単位を構成単位として含むという特徴があり …