Chondroitin sulfate-D promotes neurite outgrowth by acting as an extracellular ligand for neuronal integrin αVβ3

M Shida, T Mikami, J Tamura, H Kitagawa - Biochimica et Biophysica Acta …, 2019 - Elsevier
Background Chondroitin sulfate (CS) chains are prominent extra/pericellular matrix
components in the central nervous system (CNS) and can exert positive or negative …

Functions of chondroitin sulfate/dermatan sulfate chains in brain development: critical roles of E and iE disaccharide units recognized by a single chain antibody …

A Purushothaman, J Fukuda, S Mizumoto… - Journal of Biological …, 2007 - ASBMB
Chondroitin sulfate (CS) and dermatan sulfate (DS) have been implicated in the processes
of neural development in the brain. In this study, we characterized developmentally …

Chondroitin sulfate/dermatan sulfate hybrid chains from embryonic pig brain, which contain a higher proportion of L-iduronic acid than those from adult pig brain …

X Bao, S Nishimura, T Mikami, S Yamada, N Itoh… - Journal of Biological …, 2004 - ASBMB
We have shown that over-sulfated chondroitin sulfate/dermatan sulfate (CS/DS) chains from
various marine organisms exhibit growth factor binding activities and neurite outgrowth …

[HTML][HTML] An Overview of in vivo Functions of Chondroitin Sulfate and Dermatan Sulfate Revealed by Their Deficient Mice

S Mizumoto, S Yamada - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Chondroitin sulfate (CS), dermatan sulfate (DS) and heparan sulfate (HS) are covalently
attached to specific core proteins to form proteoglycans in their biosynthetic pathways. They …

Oversulfated chondroitin sulfate plays critical roles in the neuronal migration in the cerebral cortex

M Ishii, N Maeda - Journal of biological chemistry, 2008 - ASBMB
Chondroitin sulfate (CS) proteoglycans bind with various proteins through CS chains in a CS
structure-dependent manner, in which oversulfated structures, such as iB (IdoA (2-O-sulfate) …

Synthesis of structurally defined chondroitin sulfate: Paving the way to the structure-activity relationship studies

Y Ji, S Zhang, M Qiao, R Jiao, J Li, P Song… - Carbohydrate …, 2020 - Elsevier
Chondroitin sulfate (CS) is one of the major and widespread glycosaminoglycans, a family of
structurally complex, linear, anionic hetero-co-polysaccharides. CS plays a vital role in …

The roles of chondroitin-4-sulfotransferase-1 in development and disease

M Klüppel - Progress in molecular biology and translational …, 2010 - Elsevier
The glycosaminoglycan chondroitin sulfate (CS) consists of long linear chains of repeating
disaccharide units, which are covalently attached to core proteins to form CS-proteoglycans …

Chemical approaches to deciphering the glycosaminoglycan code

CI Gama, LC Hsieh-Wilson - Current opinion in chemical biology, 2005 - Elsevier
Glycosaminoglycans are sulfated biopolymers with rich chemical diversity and complex
functions in vivo, contributing to processes ranging from cell growth and neuronal …

Modular Synthesis of Heparan Sulfate Oligosaccharides Having N-Acetyl and N-Sulfate Moieties

L Sun, P Chopra, GJ Boons - The Journal of organic chemistry, 2020 - ACS Publications
Heparan sulfates are structurally diverse sulfated polysaccharides that reside at the surface
of all animal cells where they can interact with a multitude of proteins, thereby modulating a …

Chondroitin sulphate proteoglycans: key modulators of spinal cord and brain plasticity

K Bartus, ND James, KD Bosch, EJ Bradbury - Experimental neurology, 2012 - Elsevier
Chondroitin sulphate proteoglycans (CSPGs) are a family of inhibitory extracellular matrix
molecules that are highly expressed during development, where they are involved in …