Interaction of chondroitin sulfate and dermatan sulfate from various biological sources with heparin-binding growth factors and cytokines

S Mizumoto, D Fongmoon, K Sugahara - Glycoconjugate journal, 2013 - Springer
Chondroitin sulfate (CS) and dermatan sulfate (DS) interact with various extracellular
molecules such as growth factors, cytokines/chemokines, neurotrophic factors, morphogens …

[HTML][HTML] Characteristic hexasaccharide sequences in octasaccharides derived from shark cartilage chondroitin sulfate D with a neurite outgrowth promoting activity

S Nadanaka, A Clement, K Masayama… - Journal of Biological …, 1998 - ASBMB
A mouse brain chondroitin sulfate (CS) proteoglycan, DSD-1-PG, bears the DSD-1 epitope
and has neurite outgrowth promoting properties. Shark cartilage CS-C inhibits the …

Role of the sulfation pattern of chondroitin sulfate in its biological activities and in the binding of growth factors

CD Nandini, K Sugahara - Advances in pharmacology, 2006 - Elsevier
Publisher Summary This chapter reviews the structural characteristics of various chondroitin
sulfate (CS) chains and their binding activity toward growth factors based on available data …

[HTML][HTML] Structural and functional characterization of oversulfated chondroitin sulfate/dermatan sulfate hybrid chains from the notochord of hagfish: Neuritogenic and …

CD Nandini, T Mikami, M Ohta, N Itoh… - Journal of Biological …, 2004 - ASBMB
Oversulfated chondroitin sulfate (CS)/dermatan sulfate (DS) hybrid chains were purified from
the notochord of hagfish. The chains (previously named CS-H for hagfish) have an average …

Identification of a critical sulfation in chondroitin that inhibits axonal regeneration

CS Pearson, CP Mencio, AC Barber, KR Martin… - Elife, 2018 - elifesciences.org
The failure of mammalian CNS neurons to regenerate their axons derives from a
combination of intrinsic deficits and extrinsic factors. Following injury, chondroitin sulfate …

Potential therapeutic application of chondroitin sulfate/dermatan sulfate

S Yamada, K Sugahara - Current Drug Discovery Technologies, 2008 - ingentaconnect.com
Glycosaminoglycans (GAGs) are complex polysaccharides, which play important roles in
cell growth, differentiation, morphogenesis, cell migration, and bacterial/viral infections …

The role of chondroitin sulfate proteoglycans in nervous system development

CP Mencio, RK Hussein, P Yu… - … of Histochemistry & …, 2021 - journals.sagepub.com
The orderly development of the nervous system is characterized by phases of cell
proliferation and differentiation, neural migration, axonal outgrowth and synapse formation …

Sugar-dependent modulation of neuronal development, regeneration, and plasticity by chondroitin sulfate proteoglycans

GM Miller, LC Hsieh-Wilson - Experimental neurology, 2015 - Elsevier
Chondroitin sulfate proteoglycans (CSPGs) play important roles in the developing and
mature nervous system, where they guide axons, maintain stable connections, restrict …

Structure of chondroitin sulfate

FN Lamari, NK Karamanos - Advances in pharmacology, 2006 - Elsevier
Publisher Summary This chapter presents the up‐to‐date information on the structure of
chondroitin sulfate (CS) and dermatan sulfate (DS). CS is an anionic linear polysaccharide …

Chondroitin sulfate E promotes neurite outgrowth of rat embryonic day 18 hippocampal neurons

AM Clement, K Sugahara, A Faissner - Neuroscience letters, 1999 - Elsevier
In light of controversial reports concerning the effects of chondroitin sulfates on neurite
outgrowth, several glycosaminoglycans belonging to this structural class were compared …