Bronchial asthma is a heterogeneous chronic inflammatory disease of airways. The studies
of molecular and cellular mechanisms of bronchial asthma have established that a wide …

Background Asthma is characterised by increased numbers of Th2-like cells in the airways
and IgE secretion. Generation of Th2 cells requires interleukin (IL)-4 and IL-13 acting …

Lung inflammation has many etiologies, including diseases of Th2-type immunity, such as
asthma and anti-parasitic responses. Inflammatory diseases of the lung involve complex …

Background: Asthma is associated with increased production of IL-4 and IL-13. Objective:
Because many of the effects of these cytokines are mediated by activation of signal …

Signal transducer and activator of transcription (STAT) family molecules play essential roles
during the differentiation of helper T cells from naïve precursors. Although the role of STAT3 …

The STAT3 transcription factor is critical for cytokine signaling and the acute phase
response, but its role in allergic asthma is largely undefined. To investigate the role of …

Signal transducers and activators of transcription 6 (STAT6) is essential for interleukin 4–
mediated responses, including class switching to IgE and induction of type 2 T helper cells …

Antigen-specific CD4 T helper type 2 (Th2) cells play a pivotal role in the induction of allergic
asthma, but the mechanisms regulating their recruitment into the airways are unknown …

Mice homozygous for the STAT4-null mutation were sensitized to cockroach Ag, challenged
intratracheally 21 days later, and compared with STAT4-competent allergic mice. The …

It is well-recognized that Stat6 plays a critical role in Th2 cell differentiation and the induction
of allergic inflammation. We have previously shown that Stat5a is also required for Th2 cell …