Oxidative stress-induced DNA damage by particulate air pollution

L Risom, P Møller, S Loft - Mutation Research/Fundamental and Molecular …, 2005 - Elsevier
Exposure to ambient air particulate matter (PM) is associated with pulmonary and
cardiovascular diseases and cancer. The mechanisms of PM-induced health effects are …

Oxidative stress and inflammation generated DNA damage by exposure to air pollution particles

P Møller, PH Danielsen, DG Karottki, K Jantzen… - … research/Reviews in …, 2014 - Elsevier
Generation of oxidatively damaged DNA by particulate matter (PM) is hypothesized to occur
via production of reactive oxygen species (ROS) and inflammation. We investigated this …

Air pollution, oxidative damage to DNA, and carcinogenesis

P Møller, JK Folkmann, L Forchhammer, EV Bräuner… - Cancer letters, 2008 - Elsevier
There is growing concern that air pollution exposure increases the risk of lung cancer. The
mechanism of action is related to particle-induced oxidative stress and oxidation of DNA …

Airborne particulate matter induces oxidative damage, DNA adduct formation and alterations in DNA repair pathways

EM Quezada-Maldonado, Y Sánchez-Pérez… - Environmental …, 2021 - Elsevier
Air pollution, which includes particulate matter (PM), is classified in group 1 as a carcinogen
to humans by the International Agency for Research in Cancer. Specifically, PM exposure …

Particulate matter inhibits DNA repair and enhances mutagenesis

M Mehta, LC Chen, T Gordon, W Rom… - Mutation Research/Genetic …, 2008 - Elsevier
Exposure to ambient air pollution has been associated with adverse health effects including
lung cancer. A recent epidemiology study has established that each 10μg/m3 elevation in …

Air pollution and cancer: biomarker studies in human populations

P Vineis, K Husgafvel-Pursiainen - Carcinogenesis, 2005 - academic.oup.com
Large cohort studies in the US and in Europe suggest that air pollution may increase lung
cancer risk. Biomarkers can be useful to understand the mechanisms and to characterize …

Subway particles are more genotoxic than street particles and induce oxidative stress in cultured human lung cells

HL Karlsson, L Nilsson, L Möller - Chemical research in toxicology, 2005 - ACS Publications
Epidemiological studies have shown an association between airborne particles and a wide
range of adverse health effects. The mechanisms behind these effects include oxidative …

Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways

RM Mroz, RPF Schins, H Li, LA Jimenez… - European …, 2008 - Eur Respiratory Soc
The epidemiological association between cancer and exposure to ambient air pollution
particles (particles with a 50% cut-off aerodynamic diameter of 10 μm (PM10)) has been …

Air pollution exposure–DNA adduct dosimetry in humans and rodents: evidence for non-linearity at high doses

J Lewtas, D Walsh, R Williams, L Dobiáš - Mutation Research/Fundamental …, 1997 - Elsevier
The impact of air pollution exposure on the level of total DNA adducts in human white blood
cells (WBCs) was evaluated in two populations in the Czech Republic and compared to the …

Air pollution particles mediated oxidative DNA base damage in a cell free system and in human airway epithelial cells in relation to particulate metal content and …

AK Prahalad, J Inmon, LA Dailey… - Chemical Research …, 2001 - ACS Publications
Epidemiological studies demonstrate an association between increased human morbidity
and mortality with exposure to air pollution particulate matter. We hypothesized that such …