Formation of an oxidative DNA damage, 8-hydroxydeoxyguanosine, in mouse lung DNA after intratracheal instillation of diesel exhaust particles and effects of high …

M Nagashima, H Kasai, J Yokota, Y Nagamachi… - …, 1995 - academic.oup.com
Diesel exhaust particles (DEP) cause tumors in the respiratory tracts of experimental
animals. It was previously shown that DEP produced superoxide and hydroxyl radical. To …

Biological activities of organic compounds adsorbed onto ambient air particles: comparison between the cities of Teplice and Prague during the summer and winter …

B Binková, M Černá, A Pastorková, R Jelı́nek… - Mutation Research …, 2003 - Elsevier
The capital of the Czech Republic, Prague, appears today to be one of the most polluted
residential areas in the country, whereas air pollution in the Northern Bohemia region (the …

The role of combustion-generated radicals in the toxicity of PM2. 5

B Dellinger, WA Pryor, B Cueto, GL Squadrito… - Proceedings of the …, 2000 - Elsevier
Electron paramagnetic resonance analyses of samples of ambient, fine particulate matter
(PM2. 5), as well as fly-ashes and soots from a wood-burning fireplace, a boiler cofired with …

Impact of air pollution and genotype variability on DNA damage in Prague policemen

B Novotna, J Topinka, I Solansky, I Chvatalova… - Toxicology letters, 2007 - Elsevier
DNA integrity was analyzed in the lymphocytes of 65 non-smoking city policemen during
January and September 2004 using the comet assay combined with excision repair …

Air pollution and genomic instability: The role of particulate matter in lung carcinogenesis

M Santibáñez-Andrade, EM Quezada-Maldonado… - Environmental …, 2017 - Elsevier
In this review, we summarize and discuss the evidence regarding the interaction between air
pollution, especially particulate matter (PM), and genomic instability. PM has been widely …

DNA adducts and oxidative DNA damage induced by organic extracts from PM2. 5 in an acellular assay

J Topinka, P Rossner Jr, A Milcova, J Schmuczerova… - Toxicology Letters, 2011 - Elsevier
The genotoxic activities of complex mixtures of organic extracts from the urban air particles
collected in various localities of the Czech Republic, which differed in the extent and sources …

Gene expression profiling of A549 cells exposed to Milan PM2. 5

M Gualtieri, E Longhin, M Mattioli, P Mantecca… - Toxicology letters, 2012 - Elsevier
BACKGROUND: Particulate matter (PM) has been associated to adverse health effects in
exposed population and DNA damage has been extensively reported in in vitro systems …

The role of oxidative stress in the cardiovascular actions of particulate air pollution

MR Miller - Biochemical society transactions, 2014 - portlandpress.com
Air pollution has been estimated to be responsible for several millions of deaths worldwide
per year, the majority of which have been attributed to cardiovascular causes. The …

Free radical activity of PM10: iron-mediated generation of hydroxyl radicals.

K Donaldson, DM Brown, C Mitchell… - Environmental …, 1997 - ehp.niehs.nih.gov
The purpose of this study was to test the hypothesis that particulate matter< or= 10 microns
in aerodynamic diameter (PM10) particles have the ability to generate free radical activity at …

Particulate air pollution, systemic oxidative stress, inflammation, and atherosclerosis

JA Araujo - Air Quality, Atmosphere & Health, 2011 - Springer
Air pollution has been associated with significant adverse health effects leading to increased
overall morbidity and mortality of worldwide significance. Epidemiological studies have …