Pathogenic role of air pollution particulate matter in cardiometabolic disease: evidence from mice and humans

T Marchini, A Zirlik, D Wolf - Antioxidants & redox signaling, 2020 - liebertpub.com
Significance: Air pollution is a considerable global threat to human health that dramatically
increases the risk for cardiovascular pathologies, such as atherosclerosis, myocardial …

[HTML][HTML] Genotoxic and epigenotoxic effects in mice exposed to concentrated ambient fine particulate matter (PM2.5) from São Paulo city, Brazil

AAF de Oliveira, TF de Oliveira, MF Dias… - Particle and fibre …, 2018 - Springer
Abstract Background The Metropolitan Area of São Paulo has a unique composition of
atmospheric pollutants, and positive correlations between exposure and the risk of diseases …

The relationship between biomarkers of oxidative DNA damage, polycyclic aromatic hydrocarbon DNA adducts, antioxidant status and genetic susceptibility following …

R Singh, RJ Sram, B Binkova, I Kalina, TA Popov… - Mutation Research …, 2007 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) appear to be significant contributors to the
genotoxicity and carcinogenicity of air pollution present in the urban environment for …

Particulate matter physicochemistry and toxicology: In search of causality—A critical perspective

KL Dreher - Inhalation Toxicology, 2000 - Taylor & Francis
Results from epidemiology studies have shown statistical associations between ambient air
particulate matter (PM) concentrations and mortality/morbidity, particularly among …

Personal exposure to particulate PAHs and anthraquinone and oxidative DNA damages in humans

Y Wei, IK Han, M Hu, M Shao, JJ Zhang, X Tang - Chemosphere, 2010 - Elsevier
Recent studies suggest that DNA oxidative damage be related to the chemical constituents
of ambient particles. The purpose of this study was to examine whether particulate polycyclic …

Increased micronuclei and bulky DNA adducts in cord blood after maternal exposures to traffic-related air pollution

M Pedersen, J Wichmann, H Autrup, DA Dang… - Environmental …, 2009 - Elsevier
Exposure to traffic-related air pollution in urban environment is common and has been
associated with adverse human health effects. In utero exposures that result in DNA damage …

[HTML][HTML] Ambient particulate matter compositions and increased oxidative stress: Exposure-response analysis among high-level exposed population

W Hu, Y Wang, T Wang, Q Ji, Q Jia, T Meng, S Ma… - Environment …, 2021 - Elsevier
Background Oxidative stress has been suggested to be one of the key drivers of health
impact of particulate matter (PM). More studies on the oxidative potential of PM alone, but …

[HTML][HTML] Decreased mitochondrial DNA content in association with exposure to polycyclic aromatic hydrocarbons in house dust during wintertime: from a population …

N Pieters, G Koppen, K Smeets, D Napierska… - PloS one, 2013 - journals.plos.org
Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants that are
formed in combustion processes. At the cellular level, exposure to PAHs causes oxidative …

Ambient air pollution and population health: overview

D Krewski, D Rainham - Journal of Toxicology and Environmental …, 2007 - Taylor & Francis
In November 2003 approximately 200 researchers, stakeholders, and policymakers from
more than 40 countries gathered to discuss the science and policy implications of air …

Particle-induced oxidative damage is ameliorated by pulmonary antioxidants

LL Greenwell, T Moreno, TP Jones… - Free Radical Biology and …, 2002 - Elsevier
This investigation focuses on the application of an in vitro assay in elucidating the role of
lung lining fluid antioxidants in the protection against inhaled particles, and to investigate the …