Since their characterization more than five decades ago, gap junctions and their structural
proteins—the connexins—have been associated with cancer cell growth. During that period …

Communication among cells via direct cell-cell contact by connexin gap junctions, or
between cell and extracellular environment via pannexin channels or connexin …

It is nowadays well established that gap junctions are critical gatekeepers of cell
proliferation, by controlling the intercellular exchange of essential growth regulators. In …

Gap junctions (GJ) and hemichannels (HC) formed from the protein subunits called
connexins are transmembrane conduits for the exchange of small molecules and ions …

Connexin, a four-pass transmembrane protein, contributes to assembly of gap junctions
among neighboring cells and thus facilitates gap junctional intercellular communication …

Cellular communication through gap junctions and hemichannels formed by connexins and
through channels made by pannexins allows for metabolic cooperation and control of …

Cancer was one of the first pathologies to be associated with gap-junction defect. Despite
the evidence accumulated over the last 40-year period, the molecular involvement of gap …

Homeostasis relies on the intimate interplay between extracellular, intracellular and
intercellular signaling networks. Direct communication between adjacent cells is mediated …

Connexins (Cxs), the gap junction proteins, have been found to be downregulated in many
types of cancers including gliomas. By restoring gap junctional communication in cancer cell …

Formation of metastases negatively impacts the survival prognosis of cancer patients.
Globally, if the various steps involved in their formation are relatively well identified, the …