Increased mortality and overexpression of interleukin-6 (IL-6) during inflammatory stress are
well-documented age-associated phenomena; however, the site of IL-6 overexpression is …

Abstract Expression of interleukin-6 (IL-6) upon acute inflammatory stress is significantly
augmented by aging in adipose tissue, a major source of this cytokine. In the present study …

Interleukin-6 (IL-6) is a proinflammatory cytokine that is normally tightly regulated and
expressed at low levels, except during infection, trauma, or other stress. Among several …

Inflammation is a physiological process that repairs tissues in response to endogenous or
exogenous aggressions. Nevertheless, a chronic state of inflammation may have detrimental …

Systemic inflammation is associated with increasing age. Yet, there are limited data about
the association between age and systemic inflammation within older adults, and whether …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Investigators have reported an increase, decrease, or no effect of age on interleukin-6 (IL-6)
production. Differences in experimental conditions and the health status of subjects may …

Mice homozygous for targeted deletion of the interleukin 10 gene (Il-10) have been partially
characterized as a model for human frailty. These mice have increased serum interleukin …

Obesity is a leading risk factor for type 2 diabetes (T2D). Aging is associated with an
increase in T2D incidence, which is not totally explained by the much lower prevalence of …

Highlights•Elderly people commonly show signs of low level systemic inflammation.•Causes
include presence of senescent cells, chronic infections and obesity.•Systemic inflammation …