Combinational effects of muscarinic receptor inhibition and β3‐adrenoceptor stimulation on neurogenic bladder dysfunction in rats with spinal cord injury

N Wada, T Shimizu, S Takai, N Shimizu… - Neurourology and …, 2017 - Wiley Online Library
Aims To investigate the effects of combined therapy with an anticholinergic agent and a β3‐
adrenoceptor agonist on bladder dysfunction and proliferation‐related molecule expression …

Effects of a new β3‐adrenoceptor agonist, vibegron, on neurogenic bladder dysfunction and remodeling in mice with spinal cord injury

D Gotoh, N Shimizu, N Wada… - Neurourology and …, 2020 - Wiley Online Library
Aims To examine vibegron effects on lower urinary tract dysfunction (LUTD) in mice with
spinal cord injury (SCI). Methods Female mice underwent Th8‐9 spinal cord transection and …

Comparison of the effects of β3‐adrenoceptor agonism on urinary bladder function in conscious, anesthetized, and spinal cord injured rats

JB Beauval, V Guilloteau, M Cappellini… - Neurourology and …, 2015 - Wiley Online Library
Aims To compare the dose effect relationship of a selective β3‐adrenoceptor agonist (CL‐
316,243) on cystometric parameters in anesthetized and conscious rats and to evaluate its …

Effects of an alpha1A/D‐adrenoceptor antagonist, naftopidil, and a phosphodiesterase type 5 inhibitor, tadalafil, on urinary bladder remodeling in rats with spinal cord …

K Kadekawa, T Majima, N Kawamorita… - Neurourology and …, 2017 - Wiley Online Library
Aims In order to clarify whether an alpha1A/D‐adrenoceptor (α1A/D‐AR) antagonist,
naftopidil, or a phosphodiesterase type 5 (PDE5) inhibitor, tadalafil, prevents bladder wall …

[HTML][HTML] Afferent pathway-mediated effect of α1 adrenergic antagonist, tamsulosin, on the neurogenic bladder after spinal cord injury

JH Han, SE Kim, IG Ko, J Kim… - International Neurourology …, 2017 - ncbi.nlm.nih.gov
Purpose The functions of the lower urinary tract (LUT), such as voiding and storing urine, are
dependent on complex central neural networks located in the brain, spinal cord, and …

Efficacy of vibegron, a novel β3‐adrenoreceptor agonist, for lower urinary tract dysfunction in mice with spinal cord injury

N Shimizu, D Gotoh, M Nishimoto… - … Journal of Urology, 2021 - Wiley Online Library
Objectives To investigate the effect of vibegron, a new clinically approved β3‐adrenoceptor
agonist in lower urinary tract dysfunction in mice with spinal cord injury. Methods …

[HTML][HTML] Effects of bladder function by early tamsulosin treatment in a spinal cord injury rat model

KK Lee, MY Lee, DY Han, HJ Jung… - Annals of Rehabilitation …, 2014 - ncbi.nlm.nih.gov
Objective To investigate the effects of early tamsulosin treatment on changes in bladder
characteristics after a spinal cord injury. Methods We divided 45 rats into three groups: the …

GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats

M Miyazato, K Sasatomi, S Hiragata… - The Journal of …, 2008 - auajournals.org
Purpose: We investigated the effects of intrathecal application of γ-aminobutyric acid A and
B receptor agonists on detrusor overactivity in spinal cord injured rats. Materials and …

Functional improvement in spinal cord injury-induced neurogenic bladder by bladder augmentation using bladder acellular matrix graft in the rat

S Urakami, H Shiina, H Enokida, K Kawamoto… - World journal of …, 2007 - Springer
Spinal cord injury (SCI) rostral to the lumbosacral level causes bladder hyperreflexia and
detrusor-sphincter dyssynergia (DSD), which are accompanied by bladder hypertrophy. We …

Changes in micturition after spinal cord injury in conscious rats

M Yoshiyama, FM Nezu, O Yokoyama, WC de Groat… - Urology, 1999 - Elsevier
Objectives. To determine the feasibility of urodynamic monitoring of voiding function in
conscious, female spinal cord-injured (SCI) rats and to compare the voiding function in SCI …