[HTML][HTML] Protective effects of antimuscarinics on the bladder remodeling after bladder outlet obstruction

Q Liu, D Luo, T Yang, B Liao, H Li… - Cellular Physiology and …, 2017 - karger.com
Background/Aims: Overactive bladder associated with bladder outlet obstruction (BOO) is a
highly prevalent condition, which is usually treated with antimuscarinics. However, the …

Role of M2 and M3 muscarinic acetylcholine receptor subtypes in activation of bladder afferent pathways in spinal cord injured rats

Y Matsumoto, M Miyazato, H Yokoyama, M Kita… - Urology, 2012 - Elsevier
OBJECTIVE: To evaluate the role of M2 and M3 muscarinic acetylcholine receptor (mAChR)
subtypes in the activation of bladder afferent pathways in rats with chronic spinal cord injury …

Antifibrosis treatment by inhibition of VEGF, FGF, and PDGF receptors improves bladder wall remodeling and detrusor overactivity in association with modulation of C …

J Kwon, EJ Lee, HJ Cho, JA Jang… - Neurourology and …, 2021 - Wiley Online Library
Aims Spinal cord injury (SCI) above the sacral level causes bladder dysfunction and
remodeling with fibrosis. This study examined the antifibrotic effects using nintedanib, an …

Muscarinic receptor activation in the lumbosacral spinal cord ameliorates bladder irritation in rat cystitis models

H Masuda, N Ichiyanagi, M Yokoyama… - BJU …, 2009 - Wiley Online Library
OBJECTIVE To investigate whether activation of spinal cholinergic pathways affects bladder
activity in rats with chemical cystitis induced by acetic acid (AA) and cyclophosphamide …

Suppression of detrusor-sphincter dysynergia by GABA-receptor activation in the lumbosacral spinal cord in spinal cord-injured rats

M Miyazato, K Sasatomi, S Hiragata… - American Journal …, 2008 - journals.physiology.org
We investigated the effects of intrathecal application of GABAA-or GABAB-receptor agonists
on detrusor-sphincter dyssynergia (DSD) in spinal cord transection (SCT) rats. Adult female …

TGF‐β1 and connexin‐43 expression in neurogenic bladder from rats with sacral spinal cord injury

J Zhao, M Wu, S Chen, Z Ji… - Neurourology and …, 2018 - Wiley Online Library
Aims Sacral spinal cord injury (SCI) could induce underactive bladder (UAB). Malfunction of
connexin 43 (CX43) regulated by TGF‐β1 might involve in urinary bladder dysfunction. We …

Mechanisms inducing autonomic dysreflexia during urinary bladder distention in rats with spinal cord injury

T Yoshizawa, K Kadekawa, P Tyagi, S Yoshikawa… - Spinal Cord, 2015 - nature.com
Objectives: This study investigated the mechanisms inducing autonomic dysreflexia due to
enhanced bladder-to-vascular reflexes in rats with spinal cord injury (SCI). Methods: SCI …

Effect of naftopidil, an alpha1D/A-adrenoceptor antagonist, on the urinary bladder in rats with spinal cord injury

K Kadekawa, K Sugaya, S Nishijima, K Ashitomi… - Life sciences, 2013 - Elsevier
AIMS: Alpha1D-adrenoceptors (α1D-ARs) located in the spinal cord are involved in the
control of lower urinary tract function. In order to clarify the effect of α1D-ARs on storage …

Losartan prevents bladder fibrosis and protects renal function in rat with neurogenic paralysis bladder

YL He, JG Wen, QS Pu, YB Wen… - Neurourology and …, 2021 - Wiley Online Library
Aims To investigate the effect of losartan on preventing bladder fibrosis and protecting renal
function in rats with neurogenic paralysis bladder (NPB). Materials and Methods Rats were …

Chronic spinal cord injury causes upregulation of serotonin (5‐HT)2A and 5‐HT2C receptors in lumbosacral cord motoneurons

N Cao, J Ni, X Wang, H Tu, B Gu, J Si, G Wu… - BJU …, 2018 - Wiley Online Library
Objectives To investigate whether the voiding dysfunction caused by spinal cord injury (SCI)
in rats can be improved by iv administration of the serotonin (5‐HT) 2A/2C receptor agonist …