Polydopamine modified ceria nanorods alleviate inflammation in colitis by scavenging ROS and regulating macrophage M2 polarization

B Zhang, Q Li, Q Xu, B Li, H Dong… - International Journal of …, 2023 - Taylor & Francis
Background Inflammatory bowel disease (IBD) is closely related to higher intracellular
oxidative stress. Therefore, developing a novel method to scavenge the harmful reactive …

Hollow CeO2 with ROS-Scavenging Activity to Alleviate Colitis in Mice

J Yang, J Zhou, Y Zhao, L Zhu, G Luo… - International Journal of …, 2021 - Taylor & Francis
Introduction Excessive production of reactive oxygen species (ROS) to induce high oxidative
stress is one of the main causes of colitis; thus, it has been regarded as a therapeutic target …

Cerium oxide nanoparticles acts as a novel therapeutic agent for ulcerative colitis through anti-oxidative mechanism

F Asgharzadeh, A Hashemzadeh, F Rahmani… - Life sciences, 2021 - Elsevier
Abstract Background Cerium (IV) oxide (CeO 2) exhibit anti-inflammatory activity via
scavenge free radicals and decreasing the oxygen species (ROS) production. Here we …

ROS responsive polydopamine nanoparticles to relieve oxidative stress and inflammation for ameliorating acute inflammatory bowel

M Yan, L Zhu, S Wu, Y Cao, N Mou, Q Chi, G Wang… - Biomaterials …, 2022 - Elsevier
Oxidative stress is a key factor in the development of inflammatory diseases. Elimination of
reactive oxygen species (ROS) in the inflamed colon has been confirmed as an effective …

A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease

F Zeng, Y Shi, C Wu, J Liang, Q Zhong, K Briley… - Journal of …, 2022 - Springer
Inflammatory bowel disease (IBD) is an incurable disease of the gastrointestinal tract with a
lack of effective therapeutic strategies. The proinflammatory microenvironment plays a …

An oral nano-antioxidant for targeted treatment of inflammatory bowel disease by regulating macrophage polarization and inhibiting ferroptosis of intestinal cells

J Yang, Y Bai, S Shen, X Tao, C Ma, B Fu, Q Dai… - Chemical Engineering …, 2023 - Elsevier
Inflammatory bowel disease (IBD) is a chronic inflammatory disease that characterized by
excessive reactive oxygen species (ROS) and high ferroptosis. The ROS plays an essential …

Hyaluronic acid/serotonin-decorated cerium dioxide nanomedicine for targeted treatment of ulcerative colitis

Y Gao, J Zou, B Chen, Y Cao, D Hu, Y Zhang… - Biomaterials …, 2023 - pubs.rsc.org
Ulcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease often
characterized by rapid progression and frequent comorbidities that make its treatment …

An ROS/DAMP dual-scavenging nanomedicine for normalizing macrophage polarization and microbiome in colitis

X Ding, W Jiang, M Li, S Xiong, W Wei, M Liu, H Xin… - Nano Today, 2023 - Elsevier
Abstract Treatment for ulcerative colitis (UC) remains a clinical challenge as conventional
approaches mostly use immunosuppressive agents to ameliorate pro-inflammatory colonic …

ROS Scavenging and inflammation-directed polydopamine nanoparticles regulate gut immunity and flora therapy in inflammatory bowel disease

M Bao, K Wang, J Li, Y Li, H Zhu, M Lu, Y Zhang… - Acta Biomaterialia, 2023 - Elsevier
Dysfunction of the intestinal mucosal immune system and dysbiosis of the intestinal
microflora can induce inflammatory bowel disease. However, drug-mediated clinical …

[HTML][HTML] Gold nanoparticles-embedded ceria with enhanced antioxidant activities for treating inflammatory bowel disease

M Li, J Liu, L Shi, C Zhou, M Zou, D Fu, Y Yuan, C Yao… - Bioactive Materials, 2023 - Elsevier
The excessive reactive oxygen species (ROS) is a hallmark associated with the initiation
and progression of inflammatory bowel disease (IBD), which execrably form a vicious cycle …