Dynamics of Cryptococcus neoformans-macrophage interactions reveal that fungal background influences outcome during cryptococcal meningoencephalitis in …

A Alanio, M Desnos-Ollivier, F Dromer - MBio, 2011 - Am Soc Microbiol
Cryptococcosis is a multifaceted fungal infection with variable clinical presentation and
outcome. As in many infectious diseases, this variability is commonly assigned to host …

Adaptive immunology of Cryptococcus neoformans infections—an update

J Chen, J Shao, M Dai, W Fang, Y Yang - Frontiers in immunology, 2023 - frontiersin.org
The fungal genus Cryptococcus comprises a group of pathogens with considerable
phenotypic and genotypic diversity that can lead to cryptococcosis in both healthy and …

Survival Defects of Cryptococcus neoformans Mutants Exposed to Human Cerebrospinal Fluid Result in Attenuated Virulence in an Experimental Model of Meningitis

A Lee, DL Toffaletti, J Tenor, EJ Soderblom… - Infection and …, 2010 - Am Soc Microbiol
Cryptococcus neoformans is a fungal pathogen that encounters various microenvironments
during growth in the mammalian host, including intracellular vacuoles, blood, and …

The interplay of phenotype and genotype in Cryptococcus neoformans disease

S Altamirano, KM Jackson, K Nielsen - Bioscience Reports, 2020 - portlandpress.com
Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening
meningitis primarily in immunocompromised individuals. In order to survive and proliferate …

The Crucial Role of Biofilms in Cryptococcus neoformans Survival within Macrophages and Colonization of the Central Nervous System

L Aslanyan, DA Sanchez, S Valdebenito, EA Eugenin… - Journal of Fungi, 2017 - mdpi.com
Cryptococcus neoformans is an encapsulated yeast-like fungus capable of causing life
threatening meningoencephalitis in patients with impaired immunity. This microbe primarily …

Cryptococcus neoformans induces alterations in the cytoskeleton of human brain microvascular endothelial cells

SHM Chen, MF Stins, SH Huang… - Journal of medical …, 2003 - microbiologyresearch.org
The fungal pathogen Cryptococcus neoformans has a predilection for the central nervous
system (CNS), resulting in devastating meningoencephalitis. At present, it is unclear how C …

Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease

K Vu, R Tham, JP Uhrig, GR Thompson III… - MBio, 2014 - Am Soc Microbiol
Cryptococcus spp. cause life-threatening fungal infection of the central nervous system
(CNS), predominantly in patients with a compromised immune system. Why Cryptococcus …

Clinical and Host Differences Between Infections with the Two Varieties of Cryptococcus neoformans

B Speed, D Dunt - Clinical infectious diseases, 1995 - academic.oup.com
A population-based register of cases of cryptococcosis in patients treated in Victoria,
Australia, over a 10-year period was established for studying the epidemiologic and clinical …

Cryptococcal meningitis and anti-virulence therapeutic strategies

K Vu, JA Garcia, A Gelli - Frontiers in microbiology, 2019 - frontiersin.org
Fungal infections of the central nervous system are responsible for significant morbidity and
mortality. Cryptococcus neoformans (Cn) is the primary cause of fungal meningitis. Infection …

Biofilm Formation by Cryptococcus neoformans Under Distinct Environmental Conditions

S Ravi, C Pierce, C Witt, FL Wormley - Mycopathologia, 2009 - Springer
Cryptococcus neoformans is an opportunistic fungal pathogen with a propensity to infect the
central nervous system of immune compromised individuals causing life-threatening …