Translating insights from the cancer genome into clinical practice

L Chin, JW Gray - Nature, 2008 - nature.com
Cancer cells have diverse biological capabilities that are conferred by numerous genetic
aberrations and epigenetic modifications. Today's powerful technologies are enabling these …

Cancer genomics: from discovery science to personalized medicine

L Chin, JN Andersen, PA Futreal - Nature medicine, 2011 - nature.com
Recent advances in genome technologies and the ensuing outpouring of genomic
information related to cancer have accelerated the convergence of discovery science and …

How cancer genomics is transforming diagnosis and treatment

B Nogrady - Nature, 2020 - nature.com
When cancer was first described by the ancient Greek physician Hippocrates, he identified
just two forms: the non-ulcer-forming carcinos and the ulcer-forming carcinoma. In the late …

[HTML][HTML] International network of cancer genome projects

International Cancer Genome Consortium - Nature, 2010 - ncbi.nlm.nih.gov
Abstract The International Cancer Genome Consortium (ICGC) was launched to coordinate
large-scale cancer genome studies in tumors from 50 different cancer types and/or subtypes …

Cancer: looking outside the genome

J Folkman, P Hahnfeldt, L Hlatky - Nature Reviews Molecular Cell …, 2000 - nature.com
The 'gene-centric'approach has produced a wealth of information about the origins and
progression of cancer, and investigators seek a full compilation of altered gene expressions …

[HTML][HTML] Cancer complexity slows quest for cure

EC Hayden - Nature, 2008 - siliconinvestor.com
The controversial Cancer Genome Atlas, run by the US National Institutes of Health, is
analysing genetic and epigenetic changes in cancers. Still in its pilot phase, the project …

The causes and consequences of genetic heterogeneity in cancer evolution

RA Burrell, N McGranahan, J Bartek, C Swanton - Nature, 2013 - nature.com
Recent studies have revealed extensive genetic diversity both between and within tumours.
This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a …

Exploring the genomes of cancer cells: progress and promise

MR Stratton - science, 2011 - science.org
The description and interpretation of genomic abnormalities in cancer cells have been at the
heart of cancer research for more than a century. With exhaustive sequencing of cancer …

Translating genomics for precision cancer medicine

R Sameek, AM Chinnaiyan - Annual review of genomics and …, 2014 - annualreviews.org
The Human Genome Project not only provided the essential reference map for the human
genome but also stimulated the development of technology and analytic tools to process …

[HTML][HTML] Epigenetics: Unravelling the cancer code

V Brower - Nature, 2011 - nature.com
Epigenetics: Unravelling the cancer code | Nature Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …