OBJECTIVE: To investigate the role of low-grade inflammation and insulin resistance
(HOMA2-IR) in adiposity-related increases in serum complement factor 3 (C3). Although C3 …

Eur J Clin Invest 2011; 41 (4): 372–379 Abstract Background Complement C3, a central
component of the innate immune system is increased in subjects with obesity and type 2 …

Background: An intricate network of reciprocal interactions between adipose tissue and
immune system have been largely demonstrated, leading to the well-accepted concept of …

Background In several reports, C3 and C4 have been linked to diabetes and cardiovascular
disease (CVD). Here, we investigate this link and the degree of C3 activation in elderly …

OBJECTIVE: Chronic inflammation plays a role in the pathogenesis of metabolic syndrome
(MetS) and cardiovascular disease (CVD). Complement component 3 (C3) is a novel …

Objective: Increased C3 has been related to body mass index (BMI) and insulin resistance,
although there are not sufficient studies in subjects with morbid obesity. The purpose of this …

Background and aims To evaluate if complement C3 is associated with insulin secretion, as
suggested by recent in vitro studies, independently of confounders including adiposity …

Objective Complement C3 and other components of the alternative pathway are higher in
individuals with obesity. Moreover, C3 has been identified as a risk factor for cardiovascular …

Introduction Obesity is frequently characterized by chronic inflammation and insulin
resistance (IR). Obesity-associated inflammation is responsible for the complement system …

OBJECTIVE—This study was performed to ascertain the relative relevance of some
inflammatory markers in insulin resistance. RESEARCH DESIGN AND METHODS—Four …