Suppression of detrusor-sphincter dysynergia by GABA-receptor activation in the lumbosacral spinal cord in spinal cord-injured rats

M Miyazato, K Sasatomi, S Hiragata… - American Journal …, 2008 - journals.physiology.org
We investigated the effects of intrathecal application of GABAA-or GABAB-receptor agonists
on detrusor-sphincter dyssynergia (DSD) in spinal cord transection (SCT) rats. Adult female …

GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats

M Miyazato, K Sasatomi, S Hiragata… - The Journal of …, 2008 - auajournals.org
Purpose: We investigated the effects of intrathecal application of γ-aminobutyric acid A and
B receptor agonists on detrusor overactivity in spinal cord injured rats. Materials and …

α1D-Adrenoceptor blockade increases voiding efficiency by improving external urethral sphincter activity in rats with spinal cord injury

H Ishida, H Yamauchi, H Ito, H Akino… - American Journal of …, 2016 - journals.physiology.org
Ideal therapy for lower urinary tract dysfunction in patients with spinal cord injury (SCI)
should decrease detrusor overactivity, thereby promoting urine storage at low intravesical …

Altered glutamate receptor function during recovery of bladder detrusor-external urethral sphincter coordination in a rat model of spinal cord injury

V Pikov, JR Wrathall - Journal of Pharmacology and Experimental …, 2002 - ASPET
Coordination of the bladder detrusor and the external urethral sphincter is a supraspinally
controlled reflex that is essential for efficient micturition. This coordination is permanently lost …

Influence of spinal cord injury on the morphology of bladder afferent and efferent neurons

MN Kruse, LA Bray, WC De Groat - Journal of the autonomic nervous …, 1995 - Elsevier
Severe micturition dysfunction can occur following spinal cord injury (SCI) due to abnormal
contractions of the urethral sphincter during bladder contractions (bladder/sphincter …

Combinational effects of muscarinic receptor inhibition and β3‐adrenoceptor stimulation on neurogenic bladder dysfunction in rats with spinal cord injury

N Wada, T Shimizu, S Takai, N Shimizu… - Neurourology and …, 2017 - Wiley Online Library
Aims To investigate the effects of combined therapy with an anticholinergic agent and a β3‐
adrenoceptor agonist on bladder dysfunction and proliferation‐related molecule expression …

Roles of Glycinergic and Gamma‐aminobutyric‐ergic Mechanisms in the Micturition Reflex in Rats

M Miyazato, N Yoshimura, S Nishijima… - LUTS: Lower Urinary …, 2009 - Wiley Online Library
The micturition reflex is one of the autonomic reflexes mediated by the spinobulbospinal
reflex pathway that passes through the pontine micturition center. In the central nervous …

Rectal distention inhibits the spinal micturition reflex via glycinergic or GABAergic mechanisms in rats with spinal cord injury

M Miyazato, K Sugaya, S Nishijima, M Morozumi… - Urologia …, 2005 - karger.com
Background: We examined the influence of rectal distention on the spinal micturition reflex
and the mechanism underlying its inhibition of bladder contraction. Methods: Fourteen …

Suppression of detrusor-sphincter dyssynergia by immunoneutralization of nerve growth factor in lumbosacral spinal cord in spinal cord injured rats

S Seki, K Sasaki, Y Igawa, O Nishizawa… - The Journal of …, 2004 - auajournals.org
Purpose: We investigated the effects of intrathecal application of nerve growth factor (NGF)
antibodies (NGF-Abs) and desensitization of C-fiber afferent pathways by capsaicin …

Rectal distention inhibits bladder activity via glycinergic and GABAergic mechanisms in rats

M Miyazato, K Sugaya, S Nishijima… - The Journal of …, 2004 - auajournals.org
Purpose: We examined the influence of rectal distention on the spinobulbospinal micturition
reflex and the mechanism underlying the inhibition of bladder contraction. Materials and …