The positive association of decreased risk of colorectal cancer with nonsteroidal
antiinflammatory drug (NSAID) use, combined with the observation that cyclooxygenase …

Nonsteroidal antiinflammatory drugs (NSAIDs) are postulated to protect against colorectal
cancer and adenomas at least in part by a cyclooxygenase (COX)–mediated mechanism …

BACKGROUND & AIMS: Multiple studies show that continuous use of nonsteroidal anti-
inflammatory drugs (NSAIDs) lowers the risk of colon cancer in humans and carcinogen …

Abstract Background/Aims: Several clinical, epidemiological, and animal studies indicate
that nonsteroidal anti-inflammatory drugs (NSAIDs) may alter the incidence of colorectal …

The cyclooxygenase (COX) pathway is important in colorectal carcinogenesis with the
majority of cancers overexpressing COX-2; however, the role of COX-2 in the development …

ContextEpidemiological studies have implicated the inducible form of cyclooxygenase (COX-
2) in the pathogenesis of colorectal cancer; however, its role is not fully understood …

Use of nonsteroidal anti‐inflammatory drugs such as aspirin, which are known to inhibit
cyclooxygenase activity, reduces the relative risk of colorectal cancer in humans by 40–50 …

Cyclooxygenase-2 (COX-2) is an important target for the suppression of colorectal
tumorigenesis by non-steroidal anti-inflammatory drugs (NSAIDs). To evaluate the role of …

Methods Whole polypectomy specimens were retrieved from 123 patients by endoscopic or
surgical resection. Following formalin fixation and paraffin embedding, the polyps were …

Non‐steroidal anti‐inflammatory drugs are chemopreventive for colorectal cancer. This
effect is due in part to their ability to inhibit the inducible isoform of cyclooxygenase (COX‐2) …