The purpose of the following study is to describe the localization of COX-2 protein and COX-
2 mRNA during human colorectal tumorigenesis and to identify potential cellular targets for …

Abstract Background: Cyclooxygenase (COX)-2 may be linked to carcinogenesis. In the
previous study, we examined COX-2 expression immunohistochemically in 95 adenomas …

Background: Cyclooxygenase-2 (COX-2) has been implicated in colorectal carcinogenesis
but its role is not completely defined. Materials and Methods: The expression of COX-2 was …

Two isoforms of cyclooxygenase, COX-1 and COX-2, have been identified and shown to be
involved in ‍tumorigenesis. Although, overexpression of COX-2 in human cancers has been …

Polska Platforma Medyczna Polish Platform of Medical Research https://ppm.edu.pl
Repozytorium Pomorskiego Uniwersytetu Medyczneg Page 1 Polska Platforma Medyczna Polish …

There is now substantial evidence for the role of cyclooxygenase (COX)‐2 in causation and
prevention of cancer. Selective COX‐2 inhibitors (coxibs) were considered attractive …

Nonsteroidal anti-inflammatory drugs reduce the incidence and mortality of colorectal
carcinoma. Their chemopreventive effects appear to be due to inhibition of cyclooxygenase …

Cyclooxygenase (COX) is a key enzyme in the formation of prostaglandins, and an inducible
isoform of COX, COX‐2, has been implicated in colorectal carcinogenesis. This study …

Several studies indicate that nonsteroidal anti-inflammatory drugs including indomethacin,
aspirin, sulindac, and piroxicam reduce the risk of colon cancer. Furthermore, nonsteroidal …

Mortality in patients with advanced colorectal cancer (CRC) remains high. Epidemiologic
studies show that individuals taking nonselective, nonsteroidal anti-inflammatory drugs …