There is a wealth of evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) can
prevent colorectal cancer. In this article the role of cyclooxygenase 1 and 2, the principle …

Aim The aim of this paper is to examine COX-2 expression in human recurrent colorectal
carcinoma tissues using immunohistochemistry and quantative real-time PCR (qPCR) …

Inhibitors of the inducible cyclooxygenase (COX‐2) have emerged as a promising new class
of drugs that may be useful for the prevention of colorectal cancer. Experimental evidence to …

A considerable amount of evidence collected from several different experimental systems
indicates that cyclooxygenase-2 (COX-2) may play a role in colorectal tumorigenesis. Large …

The rate-limiting step in arachidonate metabolism is mediated by enzymes known as
cyclooxygenases (COXs). These enzymes catalyze the biosynthesis of prostaglandin H 2 …

During recent years, multidisciplinary studies in epidemiology and molecular biology, as
well as preclinical studies, have contributed much to our understanding of the etiology of …

A putative target for the anti-colorectal cancer action of nonsteroidal anti-inflammatory drugs
is the inducible isoform of cyclooxygenase (COX), COX-2. COX-2 is expressed within …

Non-steroidal anti-inflammatory drugs (NSAIDs) reduce tumour mass by increasing the rate
of tumour cell apoptosis and decreasing cell proliferation. The classically recognized target …

The role of cyclooxygenase-2 (COX-2) in colorectal tumorigenesis in mice was studied by
Oshima et al. to determine the effects of COX-2 gene knockouts and a new COX-2 inhibitor …

Recent epidemiological and experimental investigations suggest a close relationship
between cyclooxygenase (COX) and pathogenesis of colorectal cancer.'There are two …