Epidemiological and experimental studies indicate an inverse relationship between the risk
of colon cancer development and intake of aspirin and other nonsteroidal antiinflammatory …

AIM: To correlate cyclooxygenase-2 (COX-2) expression profile with clinical and
pathological variables to assess their prognostic/predictive value in colorectal carcinoma …

Objective COX-2, the inducible isoenzyme, was found to be overexpressed in approximately
85% of colorectal adenocarcinomas, contributing to key steps in tumor development. COX-2 …

Epidemiological and laboratory studies suggest that nonsteroidal anti-inflammatory drugs
reduce the risk of colon cancer and that the inhibition of colon carcinogenesis is mediated …

Abstract Cyclooxygenase 2 (COX2) is an inducible enzyme synthesizing prostaglandins
from arachidonic acid, which is thought to play an important role in colorectal …

Colorectal cancer (CRC) is a heterogeneous disease, including at least three major forms:
hereditary, sporadic and colitis-associated CRC. A large body of evidence indicates that …

Epidemiological and laboratory studies indicate an inverse relationship between the risk of
colon cancer development and intake of nonsteroidal antiinflammatory agents, including …

The cyclooxygenase (COX) enzymes (COX-1 and COX-2) are key enzymes of prostaglandin
(PG) biosynthesis. Nonselective non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the …

Background Cyclo-oxygenase inhibition for the treatment of colorectal neoplasia has been
studied with renewed interest since the discovery of cyclo-oxygenase (Cox) 2 and the …

The cyclooxygenase (COX) family of enzymes has been implicated in cell proliferation and
angiogenesis in many tumors, including colon cancer. Indeed, cyclooxygenase-2 (COX-2) …