Notch signaling is essential to the regulation of cell differentiation, and aberrant activation of
this pathway is implicated in human fibrotic diseases, such as pulmonary, renal, and …

This study investigated the roles of Notch‑1 in colorectal carcinoma, to assess the
mechanisms. The expression of Notch‑1 and its ligand-Jagged1 was detected in human …

Discerning oncogenic drivers from passengers remain a major effort in understanding of the
essence of the initiation and development of hepatocellular carcinoma (HCC), which is the …

Liver cancer comprises a group of malignant tumors, among which hepatocellular
carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most common. ICC is …

Notch signaling is an evolutionarily conserved mechanism, used to regulate cell fate
decisions. Four Notch receptors have been identified in man (Notch-1 to-4). In this study …

Notch signaling abnormalities are reported to be involved in the acceleration of malignancy
in solid tumors and stem cell formation or regeneration in various organs. We analyzed …

Hepatocyte nuclear factor-1beta plays an important role in the development and progression
of liver cancer. In recent years, the expression of HNF-1β has been reported to be …

Vasculogenic mimicry (VM) is the process where cancer cells adopt endothelial
characteristics by forming tube-like structures and perfusing channels. This phenomenon …

The Notch signaling pathway plays a key role in the morphogenesis of the biliary tree, but its
involvement in cystic biliary diseases, such as Caroli disease (CD) and polycystic liver …

We aimed to examine Notch2 expression in oesophageal squamous cell carcinoma (ESCC)
patients and to evaluate its prognostic potential. Immunohistochemical (IHC) staining …