In addition to the immediate microenvironment, long-range signaling may be an important
component of cancer. Molecular-genetic analyses have implicated gap junctions—key …

Gap junctions are cell‐to‐cell junctions that are located in the basolateral surface of two
adjoining cells. A gap junction channel is composed of a family of proteins called connexins …

The concept of gap junctions and their role in intercellular communication has been known
for around 50 years. Considerable progress has been made in understanding the …

In a recent review article,“Risk Assessment for Possible Carcinogens: A Critical Look”(1), Dr.
Emmanuel Farber states,“There is a developing speculation that agents or circumstances …

Stem cells provide an invaluable tool to develop cell replacement therapies for a range of
serious disorders caused by cell damage or degeneration. Much research in the field is …

The role of gap junctional intercellular communication (GJIC) in regulation of normal growth
and differentiation is becoming increasingly recognized as a major cellular function. GJIC …

Malfunctioned gap junctional intercellular communication (GJIC) has been thought
associated with malignant transformation of normal cells. However, the role of GJIC-related …

Gap junction intercellular communication (GJIC) is considered to play roles in regulation of
homeostasis, development and differentiation of many tissues. In the present study, using …

Background Colorectal cancer is one of the most common cancers in the United States with
an early detection rate of only 39%. Colorectal cancer cells along with other cancer cells …

Background Gap junction intercellular communication (GJIC) is considered to play a role in
the regulation of homeostasis because it regulates important processes, such as cell …