Rationale: Adenylyl cyclase (AC) represents one of the principal molecules in the β-
adrenergic receptor signaling pathway, responsible for the conversion of ATP to the second …

Rationale: Disruption in subcellular targeting of Ca2+ signaling complexes secondary to
changes in cardiac myocyte structure may contribute to the pathophysiology of a variety of …

Cyclic AMP exhibits local (sarcolemmal) and global (cytosolic) patterns of signalling,
allowing receptor-specific signals to be generated by a single second messenger. Here we …

Voltage-dependent calcium channels (VDCCs) play a pivotal role in normal excitation-
contraction coupling in cardiac myocytes. These channels can be modulated through …

Recent studies of cholesterol-rich membrane microdomains, called caveolae, reveal that
caveolae are reservoirs of “recruitable” sodium ion channels. Caveolar channels constitute a …

Cardiovascular disease is the main cause of death globally, accounting for over 17 million
deaths each year. As the incidence of cardiovascular disease rises markedly with age, the …

Beta-adrenoceptors (βAR) are often viewed as archetypal G-protein coupled receptors. Over
the past fifteen years, investigations in cardiovascular biology have provided remarkable …

Cardiac excitation involves the generation of action potential by individual cells and the
subsequent conduction of the action potential from cell to cell through intercellular gap …

Differential modes for β 1-and β 2-adrenergic receptor (AR) regulation of adenylyl cyclase in
cardiomyocytes is most consistent with spatial regulation in microdomains of the plasma …

The cardiac L-type calcium channel is a multi-subunit complex that requires co-assembling
of the pore-forming subunit CaV1. 2 with auxiliary subunits CaVα2δ and CaVβ. Its traffic has …