Sensitization to the adipokine leptin is a promising therapeutic strategy against obesity and
its comorbidities and has been proposed to contribute to the lasting metabolic benefits of …

Background & Aims Leptin, the protein product of the ob gene, increases energy
expenditure and reduces food intake, thereby promoting weight reduction. Leptin also …

Background Roux-en-Y gastric bypass (RYGB) surgery is an effective metabolic surgery
against diabetes and obesity. Clinical evidence indicates that patients with severe obesity …

Objective: Weight regain contributes to the therapeutic failure in 15–20% of type 2 diabetic
patients after Roux-en-Y gastric bypass surgery (RYGB), and the mechanism remains …

Background Previously, we demonstrated that Roux-en-Y gastric bypass (RYGB) decreases
body weight, improves histological features of steatosis, and reduces hepatic triglyceride …

In order to combat overweight and obesity as a global public health issue and prevent its
impact on other debilitating cardiovascular, metabolic and renal diseases, a better …

Bariatric surgery improves glucose homeostasis and alters gut hormones partly independent
of weight loss. Leptin plays a role in these processes; levels are decreased following …

The molecular mechanisms implicated in pronounced weight loss and metabolic benefits
after bariatric surgery are still unknown. Adipocyte phenotype and metabolism have not …

Bariatric surgery improves glucose homeostasis and alters gut hormones partly independent
of weight loss. Leptin plays a role in these processes; levels are decreased following …

Giving Leptin a Second Chance | Science Translational Medicine news careers commentary
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