Targeted delivery of nano-therapeutics for major disorders of the central nervous system

H Gao, Z Pang, X Jiang - Pharmaceutical research, 2013 - Springer
Major central nervous system (CNS) disorders, including brain tumors, Alzheimer's disease,
Parkinson's disease, and stroke, are significant threats to human health. Although …

[HTML][HTML] Progress and perspectives on targeting nanoparticles for brain drug delivery

H Gao - Acta Pharmaceutica Sinica B, 2016 - Elsevier
Due to the ability of the blood–brain barrier (BBB) to prevent the entry of drugs into the brain,
it is a challenge to treat central nervous system disorders pharmacologically. The …

Recent advances in biomimetic nanodelivery systems: new brain-targeting strategies

J Liao, L Fan, Y Li, QQ Xu, LY Xiong, SS Zhang… - Journal of Controlled …, 2023 - Elsevier
In recent years, brain diseases have seriously threatened human health due to their high
morbidity and mortality. Achieving efficient drug delivery to provide satisfactory therapeutic …

Beyond the blood–brain barrier: facing new challenges and prospects of nanotechnology-mediated targeted delivery to the brain

M Kumar, P Sharma, R Maheshwari, M Tekade… - … -Based Targeted Drug …, 2018 - Elsevier
The blood–brain barrier (BBB) is a stealth barrier that protects the brain, and allows the entry
of only a select pool of compounds into the brain and functions towards the maintenance of …

[HTML][HTML] Nanotechnology-based drug delivery for central nervous system disorders

TT Nguyen, TTD Nguyen, TK Vo, MK Nguyen… - Biomedicine & …, 2021 - Elsevier
Drug delivery to central nervous system (CNS) diseases is very challenging since the
presence of the innate blood–brain barrier (BBB) and the blood-cerebrospinal fluid barrier …

Therapeutic nanoplatforms and delivery strategies for neurological disorders

YJ Kang, EG Cutler, H Cho - Nano Convergence, 2018 - Springer
The major neurological disorders found in a central nervous system (CNS), such as brain
tumors, Alzheimer's diseases, Parkinson's diseases, and Huntington's disease, have led to …

Nanotechnology-based drug delivery for the treatment of CNS disorders

KR Mittal, N Pharasi, B Sarna, M Singh… - Translational …, 2022 - degruyter.com
Approximately 6.8 million people die annually because of problems related to the central
nervous system (CNS), and out of them, approximately 1 million people are affected by …

Nanobiotechnology-based strategies for crossing the blood–brain barrier

KK Jain - Nanomedicine, 2012 - Taylor & Francis
The blood–brain barrier (BBB) is meant to protect the brain from noxious agents; however, it
also significantly hinders the delivery of therapeutics to the brain. Several strategies have …

Targeted drug delivery to central nervous system (CNS) for the treatment of neurodegenerative disorders: trends and advances

K Goyal, V Koul, Y Singh… - Central Nervous System …, 2014 - ingentaconnect.com
The treatment of brain diseases has been a major challenge since a long time. Although
there are several potent drugs, which are highly therapeutic yet their efficiency is marred due …

Brain‐targeting drug delivery systems

P Liu, C Jiang - Wiley Interdisciplinary Reviews: Nanomedicine …, 2022 - Wiley Online Library
Brain diseases, including neurodegenerative diseases, acute ischemic stroke and brain
tumors, have become a major health problem and a huge burden on society with high …