Nuciferine Protects Against High-Fat Diet-Induced Hepatic Steatosis via Modulation of Gut Microbiota and Bile Acid Metabolism in Rats

J Sun, J Fan, T Li, X Yan, Y Jiang - Journal of Agricultural and …, 2022 - ACS Publications
Our previous study showed that nuciferine (NF) attenuated non-alcoholic fatty liver disease
(NAFLD), which is attributed to a high-fat diet (HFD) through reinforcing intestinal barrier …

Nuciferine ameliorates high‐fat diet‐induced disorders of glucose and lipid metabolism in obese mice based on the gut–liver axis

X Zhu, R Hao, X Lv, X Zhou, D Li, C Zhang - Food Frontiers, 2024 - Wiley Online Library
High‐fat diets (HFDs) can trigger lipid accumulation, insulin resistance, and inflammatory
responses in the body, causing glucose and lipid metabolism dysfunction. This study aimed …

Dietary isoquercetin reduces hepatic cholesterol and triglyceride in NAFLD mice by modulating bile acid metabolism via intestinal FXR-FGF15 signaling

C Zhang, Z Shi, H Lei, F Wu, C Chen… - Journal of Agricultural …, 2023 - ACS Publications
Isoquercetin, a monosaccharide flavonoid, was recently reported to have significant
amelioration effects on high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) …

L‐Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism

W Xu, Y Kong, T Zhang, Z Gong… - Journal of the Science of …, 2023 - Wiley Online Library
BACKGROUND l‐Theanine (LTA) is a biologically active ingredient in tea that shows great
potential for regulating lipid metabolism. Bile acids (BA), an important end‐product of …

Apple polyphenol extract improves high-fat diet-induced hepatic steatosis by regulating bile acid synthesis and gut microbiota in C57BL/6 male mice

D Li, Y Cui, X Wang, F Liu, X Li - Journal of agricultural and food …, 2021 - ACS Publications
Our previous study showed that apple polyphenol extract (APE) ameliorated high-fat diet-
induced hepatic steatosis in C57BL/6 mice by targeting the LKB1/AMPK pathway; to …

Tectorigenin ameliorated high-fat diet-induced nonalcoholic fatty liver disease through anti-inflammation and modulating gut microbiota in mice

R Duan, K Huang, X Guan, S Li, M Shen, Z Sun… - Food and Chemical …, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is a complex pathogenesis of liver disease
combined with liver inflammation and gut microbiota dysbiosis. Tectorigenin (Tg) is derived …

Nuciferine improves high-fat diet-induced obesity via reducing intestinal permeability by increasing autophagy and remodeling the gut microbiota

Z Shi, Z Fang, X Gao, H Yu, Y Zhu, H Ouyang… - Food & Function, 2021 - pubs.rsc.org
Nuciferine (NF) has received extensive attention due to its medicinal value in the treatment
of metabolic diseases, such as obesity; however, to date, the effects of NF on obesity-related …

Bilberry anthocyanins ameliorate NAFLD by improving dyslipidemia and gut microbiome dysbiosis

H Nakano, S Wu, K Sakao, T Hara, J He, S Garcia… - Nutrients, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a manifestation of metabolic syndrome closely
linked to dyslipidemia and gut microbiome dysbiosis. Bilberry anthocyanins (BA) have been …

Flavonoids from Whole-Grain Oat Alleviated High-Fat Diet-Induced Hyperlipidemia via Regulating Bile Acid Metabolism and Gut Microbiota in Mice

R Duan, X Guan, K Huang, Y Zhang, S Li… - Journal of Agricultural …, 2021 - ACS Publications
A high-fat diet (HFD) causes hyperlipidemia, which worsens disturbances in bile acid (BA)
metabolism and gut microbiota. This study aimed to investigate the regulation of flavonoids …

Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota

Y Li, J Li, Q Su, Y Liu - Food & Function, 2019 - pubs.rsc.org
Non-alcoholic fatty liver disease (NAFLD) is associated with low-grade chronic inflammation
and intestinal dysbiosis. In this study, we investigated the potential benefits of sinapine, a …