Expression of the p14ARF tumour suppressor is induced by hyperproliferative signals
produced by RAS, MYC and other oncogenes. p14ARF quenches inappropriate mitogenic …

p14ARF, the alternative product from the human INK4a/ARF locus, is one of the major
targets for alterations in the development of human cancers. Overexpression of p14ARF …

While p14ARF suppression of tumorigenesis in a p53-dependent manner is well studied, the
mechanism by which p14ARF inhibits tumorigenesis independently of p53 remains elusive …

p19ARF is a potent tumor suppressor. By inactivating Mdm2, p19ARF upregulates p53
activities to induce cell cycle arrest and sensitize cells to apoptosis in the presence of …

The tumor suppressor p14ARF, encoded by the INK4a/ARF locus, is often disrupted in
human cancers. p14ARF triggers cell cycle arrest and sensitizes cells to apoptosis in the …

p19ARF suppresses the growth of cells lacking p53 through an unknown mechanism.
p19ARF was found to complex with transcription factors E2F1,-2, and-3. Levels of …

Recent studies have shown the p19 ARF tumor suppressor to be involved in the response to
oncogenic stress by regulating the activity of p53. This response is mediated by …

The p14 ARF tumor suppressor is a key regulator of cellular proliferation and is frequently
inactivated in human cancer. This tumor suppressor functions in the p53 and pRb cell cycle …

Ectopic expression of oncogenes such as Ras induces expression of p19Arf, which, in turn,
activates p53 and growth arrest. Here, we used a multistage model of squamous cell …

Normal healthy cells possess safeguard mechanisms that sense oncogenic signals and
trigger anti-tumorigenic responses that limit the proliferative potential of cells harbouring …