The RAS gene family is among the most studied and best characterized of the known cancer-
related genes. Of the three human ras isoforms, KRAS is the most frequently altered gene …

Simple Summary Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutated colorectal
cancer (CRC) seems to have a different biological behavior and therapeutic approach …

Somatic KRAS mutation is an early well‐known event in colorectal carcinogenesis but a
complete understanding of RAS function and dysfunction in colorectal cancer is still to come …

Mutations in RAS proteins occur widely in human cancer. Prompted by the confirmation of
KRAS mutation as a predictive biomarker of response to epidermal growth factor receptor …

Colorectal cancer (CRC) is a heterogeneous disease at the cellular and molecular levels.
Kirsten rat sarcoma (KRAS) is a commonly mutated oncogene in CRC, with mutations in …

The most commonly mutated isoform of RAS among all cancer subtypes is KRAS. In this
review, we focus on the special role of KRAS mutations in colorectal cancer (CRC), aiming …

Purpose The increased incidence of colorectal cancer (CRC) has necessitated the
development of novel prognostic and predictive factors from which new diagnostic tests …

KRAS (kirsten rat sarcoma viral oncogene) is a member of the RAS family. KRAS mutations
are one of most dominant mutations in colorectal cancer (CRC). The impact of KRAS …

The RAS gene family provides a global effect on gene expression by encoding small GTP-
binding proteins which act as molecular switches connecting extracellular signals with …

KRAS mutation occurs in 30% to 50% of colorectal cancers (CRCs) and has been
suggested to be associated with proliferation and decreased apoptosis. In this study, we …