Lupus nephritis (LN) is a major manifestation of systemic lupus erythematosus (SLE),
causing morbidity and mortality in 40–60% of SLE patients. The pathogenic mechanisms of …

In systemic lupus erythematosus, CD4+ T cells play key roles in the initiation and promotion
of autoantigen-specific humoral immunity, and indirect evidence suggests that T cells are …

Objectives Kidney-infiltrating immune cells can contribute to the pathogenesis of lupus
nephritis (LN). We investigated the immunological characteristics of CD11c+ macrophages …

Autoreactive T cells are critical in the initiation and maintenance of autoantibody responses
that are a hallmark of systemic lupus erythematosus. However, the direct contribution of T …

Renal infiltration with mononuclear cells is associated with poor prognosis in systemic lupus
erythematosus. A renal macrophage/dendritic cell signature is associated with the onset of …

Systemic lupus erythematosus (SLE) is a complex, heterogeneous autoimmune disease. A
common manifestation, lupus nephritis, arises from immune complex deposition in the …

Objective Recent studies have revealed a potential implication of CD8+ T lymphocytes in the
pathogenesis of systemic lupus erythematosus (SLE) through their ability to induce tissue …

The mechanisms that promote local inflammatory injury during lupus nephritis (LN) flare are
largely unknown. Understanding the key immune cells that drive intrarenal inflammation will …

Innate lymphoid cells (ILCs) are important regulators of the immune response and play a
crucial role in the restoration of tissue homeostasis after injury. GATA‐3+ IL‐13‐and IL‐5 …

Lupus nephritis involves both humoral and cellular effectors. Okamoto and colleagues
isolated renal CD4+ cells from lupus-prone mice, selecting cells expressing T-cell receptors …